9.B.33 The Sensor Histidine Kinase (SHK) Family

The SHK family is a coherent group of proteins of similar structure with the N-terminal hydrophobic 'transporter' domain linked to a C-terminal hydrophilic SHK domain (Mansour et al., 2007). The N-terminal 5 TMS 'transporter' or 'receptor' domain has not been shown to have transport activity.


This family belongs to the BART Superfamily.
 

References:

Mansour, N.M., M. Sawhney, D.G. Tamang, C. Vogl, and M.H. Saier, Jr. (2007). The bile/arsenite/riboflavin transporter (BART) superfamily. FEBS J. 274: 612-629.
Examples:

TC#NameOrganismal TypeExample
9.B.33.1.1

The LytS (Ban2) protein (Mansour et al., 2007)

Bacteria

LytS of Bacillus anthracis (Q81JL2)

 
9.B.33.1.2

Signal transduction histidine kinase of 586 aas and 6 N-terminal TMSs, LytS.

LytS of Lactobacillus reuteri

 
9.B.33.1.4

Two-component system sensor histidine kinase, LytS, of 593 aas and 6 N-terminal TMSs.

LytS of Bacillus subtilis

 
9.B.33.1.5

Serine phosphatase of 353 aas and 9 TM

Serine phosphatase of Methanobrevibacter ruminantium

 
9.B.33.1.6

Six TMS-LYT of 353 aas and 6 TMSs.

TMS-LYT of Methanomassiliicoccales archaeon

 
9.B.33.1.7

Sensor histidine kinase of 587 aas and 6 N-terminal TMSs. TMSs 3 - 6 align with TMSs 3 - 6 of the 6 TMSs of 9.B.34.1.1 with a score of e-6, suggesting that the transmembrane domains of these proteins are homologous. For this reason, these two families are included within the BART superfamily.

SK of Fictibacillus enclensis

 
Examples:

TC#NameOrganismal TypeExample