9.B.333. The Uncharacterized Archaeal/Bacterial 5 TMS (UAB5) Family
Members of this family are found in archaea and bacteria and can be associated with sensor histidine kinase and response regulator domains, and probably with other domains as well. Some members of the family have 5 C-terminal TMSs and an N-terminal hydrophilic domain that is likely to play a role in transcriptional regulation. In fact, the majority of characterized NCBI Blast hits seem to function in transcriptional control. 9.B.333.1.2 may be distantly related to 9.B.29.2.13 and 9.B.346.3.2, but homology has not been established. The first two of these proteins have 5 TMSs in a 1 + 2 + 2 TMS arrangement, but the last of these proteins is a 4 TMS protein.
UP of 270 aas with an N-terminal HTH domain and 5 C-terminal TMSs in a 1 + 4 TMS arrangement.
UP of Candidatus Bathyarchaeota
Uncharacterized protein of 275 aas and 5 C-terminal TMSs.
UP of Bacteroidetes bacterium (marine sediment metagenome)
ArsR family of transcriptional regulators (N-terminal domain) with 5 C-terminal TMSs.
ArsR of Euryarchaeota archaeon
Winged helix-turn-helix transcriptional regulator of 136 aas and 0 TMSs. This protein corresponds to the N-terminal hydrophilic domain of the other members of this family.
Tx factor of Thermococcus kodakarensis