9.B.335. The Putative Integral Membrane Chaperone Protein (IMCP) Family Two very distant subfamilies within this family, the proteins listed under 9.B.135.1 and 9.B.135.2) appear to be homologous throughout their lengths, except that the latter has a C-terminal hydrophlic extension of about 100 - 150 residues that is lacking in the former. This C-terminal domain is homolgous to the C-terminal extensions in two MFS porters (TC# 2.A.1.89.1 and 2.A.1.89.2; BLAST scores of e^-11) but the functions of these domains are not known. The proteins of this family also seem to be distantly related to the putative chaparone proteins of ABC transporters listed in TC family 9.B.29, one of which is listed unter TC# 9.B.29.2.7. This was the basis for the suggested name of the family.
Examples:
TC#	Name	Organismal Type	Example
9.B.335.1.1	UP of 239 aas and 7 TMSs		UP of Candidatus Thorarchaeota archaeon

9.B.335.1.2	Uncharacterized protein of 235 aas and 7 TMSs.		UP of Candidatus Helarchaeota archaeon (marine sediment)

9.B.335.1.3	Uncharacterized protein of 260 aas and 7 TMSs.		UP of Candidatus Lokiarchaeota archaeon (sediment metagenome)

Examples:
TC#	Name	Organismal Type	Example
9.B.335.2.1	Uncharacterized protein of 354 aas and 7 TMSs. The last 3 TMSs plus the C-terminal hydrophilic domain of about 100 aas are homologous to the MFS porters with TC#s 2.A.1.89.1 and 2.A.1.89.2.		UP of Candidatus Thorarchaeota archaeon

9.B.335.2.2	Uncharacterized protein of 368 aas and 7 - 9 TMSs. The last two peaks of hydrophobicity are smaller than any of the others, and therefore may not correspond to TMSs.		UP of Candidatus Lokiarchaeota archaeon (sediment metagenome)

9.B.335.2.3	Uncharacterized protein of 394 aas and 7 TMSs. This protein, like other members of the 9.B.335.2 subfamily shows sequence similarity and are in part homologous to members of the MFS subfamily, 2.A.1.89.		UP of Candidatus Bathyarchaeota archaeon (microbial mat metagenome)