9.B.347.  The DUF2085 Domain-containing Protein (DUF2085) Family 

The DUF 2085 proteins are usually smal 4 TMS proteins of about 140 - 160 aas without hydrophilic regions, but members can have 2,  3 or 5 TMSs. The smaller proteins may be fragments, and the 5 TMS proteins have a small hydrophobic peak at their N-termini followed by the 2 + 2 TMS pattern. The dominant 4 TMSs often occur in a 2 + 2 TMS arrangement and may contain a duplication of the basic 2 TMS segment. However others have 4 TMSs in a 1 + 3 TMS arrangement.  These proteins show limited sequence similarity with the transmembrane domain of HDIG domain-containing hydrolases of TC family 9.B.28.


TC#NameOrganismal TypeExample

Uncharacterized protein of 185 aas and 4 TMSs with a DUF2085 domain.

UP of Candidatus Thorarchaeota archaeon SMTZ-45


Uncharacterized protein of 144 aas and 4 TMSs in a 2 + 2 TMS arrangement.

UP of Halopiger xanaduensis


Uncharacterized protein of 174 aas and 5 TMSs.

UP of Candidatus Marinimicrobia bacterium


DUF2085 domain-containing protein of 149 aas and 4 TMSs.

DUF2085 domain protein of Halobonus sp.


TC#NameOrganismal TypeExample

Uncharacterized protein of 187 aas and 4 TMSs in a 1 + 3 TMS arrangement.

UP of Thermoplasmata archaeon


DUF2085 domain-containing protein of 109 aas and 2 TMSs

DUF2085 protein of Bacillus cereus


Uncharacterized protein of 153 aas and 4 TMSs in a 1 + 3 TMS arrangement.

UP of Candidatus Melainabacteria bacterium GWF2_32_7 (subsurface metagenome)


Uncharacteerized protein of 168 aas and 4 TMSs in a 1 + 3 TMS arrangement.

UP of  Candidatus Altiarchaeales archaeon


TC#NameOrganismal TypeExample

Uncharacterized protein of 330 aas and 4 TMSs.  The protein has a 100 aa hydrophilic N-terminal domain followed by the transmembrane domain in a 1 + 3 TMS arrangement.

UP of Chloroflexi bacterium


TC#NameOrganismal TypeExample

Uncharacterized protein of 212 aas and 4 or 5 TMSs in a (1 +) 2 + 2 TMS arrangement.

UP of Candidatus Poseidoniales archaeon


TC#NameOrganismal TypeExample

Uncharacterized protein of 180 aas and 4 TMSs.

UP of Candidatus Prometheoarchaeum syntrophicum


Uncharacterized protein of 242 aas and 4 TMS, all closely together in the middle of the proteins.

UP of Oscillatoria acuminata PCC 6304


Uncharacterized protein of 174 aas and 4 TMSs.

UP of Haloarchaeobius iranensis


Uncharacterized DUF2085 domain-containing protein of 196 aas and 4 TMSs.

UP of Asgard group archaeon


Uncharacterized protein of 159 aas and 3 or 4 TMSs

UP of Methanomassiliicoccales archaeon (bioreactor metagenome)