9.B.350. The Pseudorabies Virus Protein UL56 (UL56) Family The pseudorabies virus (PRV) protein UL56 (pUL56) has been implicated in viral dissemination and virulence in vivo. Lyu and Cai 2019 showed that it is localized to the Golgi and trans-Golgi network (TGN) via its C-terminal leucine-rich TMS. A Golgi-associated protein Rab6a, independent of interaction with pUL56, was downregulated by pUL56. Several leucine and proline residues proved to be essential for maintaining perinuclear accumulation. Thus, the leucine-rich transmembrane helix is responsible for pUL56 Golgi-TGN localization and retention, probably due to specific intracellular membrane insertion (Lyu and Cai 2019).
References:
Lyu, C. and X. Cai. (2019). A GFP-tagged version of the pseudorabies virus protein UL56 localizes to the Golgi and trans-Golgi network through a predicted C-terminal leucine-rich helix in transfected cells. Virol J 16: 81.
Examples:
TC#	Name	Organismal Type	Example
9.B.350.1.1	The pseudorabies virus UL56 protein of 234 aas and one C-terminal leucine-rich TMS. See family description (Lyu and Cai 2019).		UL56 of Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)

9.B.350.1.2	Membrane protein of 292 aas and one C-terminal TMS		*Membrane protein of Pteropus lylei-associated α-herpesvirus*

9.B.350.1.3	Protein UL56 of 233 aas and one C-terminal TM		Protein UL56 of human alpha-herpesvirus 1 strain HFEM

9.B.350.1.4	Membrane protein UL56 of 287 aas and 1 C-terminal TM		UL56 of Fruit bat alphaherpesvirus 1