9.B.359. The Large Uncharacterized Protein (LUP9) Family The proteins of the LUP9 family consist of bacterial proteins with about 700 aas and 7 (or sometimes 9 or 5 TMS), usually N-terminal with a C-terminal hydrophilic domain. They may be related to glycosyl transferases of families 9.B.142 and/or to members of the ABC membrane protein exporter superfamilies (e.g., 3.A.1.132.13 and 3.A.1.145.1). The hydrophilic domains may be related to peptidases or glycosyl transferases.
Examples:
TC#	Name	Organismal Type	Example
9.B.359.1.1	Uncharacterized protein of 727 aas and 7 N-terminal TMSs in a 2 + 3 + 2 TMS arrangement.		UP of Paenibacillus lactis

9.B.359.1.2	Uncharacterized protein of 739 aas and 5 TMSs in a 3 + 2 TMS arrangement.		UP of an unclassified Sporomusaceae

Examples:
TC#	Name	Organismal Type	Example
9.B.359.2.1	Uncharacterized protein of 645 aas with 7 N-terminal TMSs in a 2 + 3 + 2 TMS arrangement.		UP of Kandleria vitulina

9.B.359.2.2	Uncharacterized protein of 685 aas and 7 N-terminal TMSs in a 2 + 3 + 2 TMS arrangement.		UP of Neobitarella massiliensis

9.B.359.2.3	Uncharacterized protein of 316 aas and 7 TMSs in a 2 + 3 + 2 TMS arrangement.		UP of Paludifilum halophilum

9.B.359.2.4	Uncharacterized protein of 693 aas and 7 N-terminal TMSs in a 2 + 3 + 2 TMS arrangement.		UP of Anoxybacillus flavithermus

9.B.359.2.5	M1 family metallopeptidase of 630 aas and 5 TMSs in a 3 + 2 TMS arrangement and a long M1 family hydrophilic extension. It could be N-terminally truncated, removing the first N-terminally 2 TMSs characteristic of this family.		M1 protease of Exiguobacterium indicum

Examples:
TC#	Name	Organismal Type	Example
9.B.359.3.1	Uncharacterized protein of 1118 aas and 7 N-terminal TMSs in a 2 + 3 + 2 TMS arrangement. It contains a carbohydrate binding module 6 (CBM6) at its N-terminus.		UP of Butyricimonas virosa

9.B.359.3.3	Uncharacterized protein of 1111 aas and 7 N-termial TMSs in a 2 + 3 + 3 TMS arrangement. This protein shows weak similarity (e^-5; 30 % identity) with 3.A.1.145 of the ABC superfamily. This protein is homologous to a protein with acc # HCE56652.1 which also shows significant sequence similarity with TC# 3.A.1.145 family members.		UP of Culturomica massiliensis

9.B.359.3.4	Uncharacterized protein of 1106 aas and 7 TMSs in a 2 + 3 + 2 TMS arrangement. This protein is homologous to members of subfamilies 9.B.359.3 and 1.		UP of Calditrichaeota bacterium

Examples:
TC#	Name	Organismal Type	Example
9.B.359.4.1	Uncharacterized protein of 657 aas and 7 N-terminal TMSs in a 2 + 3 + 2 TMS arrangement		*UP of Sulfobacillus* sp. hq2**

9.B.359.4.2	Uncharacterized protein of 747 aas and 7 TMSs in a 2 + 3 + 2 TMS arrangement.		UP of Thermosporothrix hazakensis