9.B.38 The Myelin Proteolipid Protein (MPLP) Family

The MPLP family consists mostly of animal proteins of 4 TMSs. The prototype is glycoprotein M6a, a CNS neuronal protein found in the granuole cell layer of the embryonic neural tube. It is present in synaptic vesicles and listed as a transporter (Takamori et al., 2006). The mouse protein is of 278 aas with 4 TMSs. Its first half is very similar to the 2 TMS Pelizaeus-Merzbacher disease protein of humans. A Tetrahymena homologue has 8 putative TMSs and is very distantly related to the mouse protein. This protein has a partial COG5152 domain at the C-terminus which exhibits similarity to zinc finger family members (e.g., ABF95025 of Oriza sativa) and ring finger protein 157 (e.g., CAM16808 of Mus musculus).


 

References:

Cai, L., Z. Liao, S. Li, R. Wu, J. Li, F. Ren, and H. Zhang. (2022). PLP1 may serve as a potential diagnostic biomarker of uterine fibroids. Front Genet 13: 1045395.
Takamori, S., M. Holt, K. Stenius, E.A. Lemke, M. Gronborg, D. Riedel, H. Urlaub, S. Schenck, B. Brugger, P. Ringler, S.A. Muller, B. Rammner, F. Grater, J.S. Hub, B.L. De Groot, G. Mieskes, Y. Moriyama, J. Klingauf, H. Grubmuller, J. Heuser, F. Wieland, and R. Jahn. (2006). Molecular anatomy of a trafficking organelle. Cell 127: 831-846.
Examples:

TC#NameOrganismal TypeExample
9.B.38.1.1The vesicular neuronal 4 TMS glycoprotein, M6a (278 aas)AnimalsGP-6a of Mus musculus (P35802)
 
9.B.38.1.2The 2 TMS Pelizaeus-Merzbacher disease (spastic paraplegia 2) protein; 136 aas

Animals

The PMD protein of Homo sapiens (B1B1G5)

 
9.B.38.1.3

Neuronal membrane glycoprotein M6-b (M6b) (Rhombencephalic expression protein-29 kDa) (Rhombex-29)

AnimalsGpm6b of Mus musculus
 
9.B.38.1.4

Proteolipid protein 1, PLP1, of 277 aas and 4 TMSs. The gene encoding this protein is upregulated with uterine fibrosis and may be a diagnostic marker for it (Cai et al. 2022).

PLP1 of Homo sapiens

 
Examples:

TC#NameOrganismal TypeExample
9.B.38.2.1The 8 TMS GP M6a homologue (577 aas)CiliatesGP-6a homologue of Paramecium tetraurelia (XP_001459279)