| The TMEM88 (TMEM88) Family
The TMEM88 family consists of small proteins of about 150 aas and 2 centrally located TMSs. The dishevelled (Dvl/Dsh) protein is one of the key components in Wnt signaling
and plays essential roles in regulating these pathways through
protein-protein interactions. TMEM88 binds to the Dishevelled (Dvl/Dsh) protein, one of key components in Wnt signaling that plays essential roles in regulating these pathways through
protein-protein interactions (Lee et al. 2010). TMEM88 attenuates the Wnt/β-catenin signaling induced by Wnt-1 ligands, and miRNA-708 acts as an oncogene contributing to tumor growth and disease progression by directly downregulating TMEM88 (Jang et al. 2012). TMEM88 also promotes triple-negative breast vancer by interacting With Dvl (Yu et al. 2015). TMEM88 mediates inflammatory cytokines secretion (Xu et al. 2018; Li et al. 2020).
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| References: |
Jang, J.S., H.S. Jeon, Z. Sun, M.C. Aubry, H. Tang, C.H. Park, F. Rakhshan, D.A. Schultz, C.P. Kolbert, R. Lupu, J.Y. Park, C.C. Harris, P. Yang, and J. Jen. (2012). Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers. Clin Cancer Res 18: 3658-3667.
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Lee, H.J., D. Finkelstein, X. Li, D. Wu, D.L. Shi, and J.J. Zheng. (2010). Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. J. Biol. Chem. 285: 41549-41556.
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Li, L.Y., C.C. Yang, S.W. Li, Y.M. Liu, H.D. Li, S. Hu, H. Zhou, J.L. Wang, H. Shen, X.M. Meng, J. Li, and T. Xu. (2020). TMEM88 modulates the secretion of inflammatory factors by regulating YAP signaling pathway in alcoholic liver disease. Inflamm Res. [Epub: Ahead of Print]
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Xu, T., L. Pan, L. Li, S. Hu, H. Zhou, C. Yang, J. Yang, H. Li, Y. Liu, X. Meng, and J. Li. (2020). MicroRNA-708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88. J Cell Mol Med. [Epub: Ahead of Print]
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Xu, T., L.X. Pan, Y.X. Ge, P. Li, X.M. Meng, C. Huang, and J. Li. (2018). TMEM88 mediates inflammatory cytokines secretion by regulating JNK/P38 and canonical Wnt/β-catenin signaling pathway in LX-2 cells. Inflammopharmacology 26: 1339-1348.
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Yu, X., X. Zhang, Y. Zhang, G. Jiang, X. Mao, and F. Jin. (2015). Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl. Oncotarget 6: 25034-25045.
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| Examples: |
| TC# | Name | Organismal Type | Example |
| 9.B.389.1.1 | Transmembrane protein 88 isoform 1 of 159 aas and 2 central TMSs. It plays a role in cancer by inhibiting the Wnt pathway (Xu et al. 2020). | | TMEM88 of Homo sapiens |
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| 9.B.389.1.2 | TMEM88 of 199 aas and 2 or 3 TMSs. | | TMEM88 of Suricata suricatta (meerkat) |
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| 9.B.389.1.3 | TMEM88B protein of 168 aas and 3 TMSs | | TMEM88B of Anabarilius grahami |
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| 9.B.389.1.4 | Uncharacterized protein of 428 aas and 6 TMSs in a 2 + 1 + 2 + 1 arrangement. The second half of this protein resembles the other members of this family. | | UP of Scophthalmus maximus (turbot) |
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