9.B.396. The Uncharacterized Prokaryotic Membrane Protein-2 (UPMP2) Family UPMP2 family proteins vary in size and topology. Some are about 230 aas with 6 TMSs; others are larger (~1000 aas with 7 N-terminal TMSs and a large C-terminal hydrophilic domain, and others are about 740 aas with 12 or 13 TMSs. These last mentioned proteins have the first 6 TMSs that belong to family 9.B.396, and the last 7 TMSs are homologous to members of the MFS (2.A.1).
Examples:
TC#	Name	Organismal Type	Example
9.B.396.1.1	Uncharacterized protein of 235 aas and 6 TMSs in a 1 + 2 + 2 + 1 TMS arrangement.		UP of Ornithinimicrobium cerasi

9.B.396.1.2	Uncharacterized protein of 740 aas and 13 TMSs in a 6 + 7 TMS arrangement. The last domain includes 6 TMSs that are homologous to the repeat unit in MFS porters. However, the first 6 TMSs are characteristic of family 9.B.396.		UP of Anaerolineaceae bacterium (marine metagenome)

9.B.396.1.3	Uncharacterized protein of 224 aas and 6 TMSs		UP of Candidatus Moranbacteria bacterium (groundwater metagenome)

9.B.396.1.4	Uncharacterized protein of 439 aas and 11 TMSs, possibly in a 5 + 1 + 5 TMS arrangement.		UP of Pontibacter russatus

9.B.396.1.5	VCBS repeat-containing protein of 983 aas and 7 N-terminal TMSs		VCBS protein of Planctomycetaceae bacterium

9.B.396.1.6	Uncharacterized protein of 241 aas and 6 TMSs		UP of Roseomonas rhizosphaerae