9.B.436.  The Plasmodium Plasma Membrane Resident Transporter 1 (PMRT1) Family 

The plasma membrane resident transporter 1 (PMRT1; PF3D7_1135300), a unique Plasmodium-specific plasma membrane transporter is essential for gametocytogenesis and functionally conserved within the genus Plasmodium (Wichers et al. 2022).


 

References:

Wichers, J.S., P. Mesén-Ramírez, G. Fuchs, J. Yu-Strzelczyk, J. Stäcker, H. von Thien, A. Alder, I. Henshall, B. Liffner, G. Nagel, C. Löw, D. Wilson, T. Spielmann, S. Gao, T.W. Gilberger, A. Bachmann, and J. Strauss. (2022). PMRT1, a -Specific Parasite Plasma Membrane Transporter, Is Essential for Asexual and Sexual Blood Stage Development. mBio 13: e0062322.

Examples:

TC#NameOrganismal TypeExample
9.B.436.1.1

The plasma membrane resident transporter 1 (PMRT1; PF3D7_1135300) of 409 aas and 8 TMSs in a 1 + 2 + 2 + 2 + 1 TMS arrangement. It is a unique Plasmodium-specific plasma membrane transporter that is essential for gametocytogenesis and functionally conserved within the genus Plasmodium (Wichers et al. 2022). Its transport function is not known.

PMRT1 of Plasmodium falciparum

 
9.B.436.1.2

Uncharacterized protein of 1350 aas and 7 or 8 N-terminal TMSs in a 1 + 2 + 2 + 2 + (1) arrangement, followed by a long hydrophylic domain, YYE_03023.

.

 

UP of Plasmodium vinckei vinckei

 
9.B.436.1.3

Uncharacterized protein of 416 aas and 8 TMSs in a 1 + 2 + 2 + 2 + 1 TMS arrangement. This protein is 85% identical to the N-terminal domain of the much larger protein listed under TC# 9.B.436.1.2.

UP of Plasmodium chabaudi adami