9.B.440.  The Large 14 - 16 TMS Putative Transporter (LPT) Family 

The LPT family consists of large proteins of either ~6 - 8 or ~12 - 16 TMSs.  These usually occur in clusters of three or four TMSs, but there seems to be substantial variation among members.  The smaller proteins seem to be half sized compared to the larger members of the family.  Other variations may also occur. (See family members of estimated cluster sizes). Parts of these proteins may show sequence similarity with members of family 9.B.422 (The TMEM26 Family).


Examples:

TC#NameOrganismal TypeExample
9.B.440.1.1

Putative transport protein of 1298 aas and possibly 16 TMSs in an apparent 6 + 2 + 2 + 6 TMS arrangement.

Putative transport protein of Plasmodium falciparum

 
9.B.440.1.10

Uncharacterized protein of 1108 aas and 14 putative TMSs in a 6 + 2 + 4 + 2 TMS arrangement.

UP of Gregarina niphandrodes

 
9.B.440.1.2

Putative transport protein of 1300 aas and ~18 TMSs in a 3 + 6 + 6 + 3 TMS arrangement.

Putative transport protein of Toxoplasma gondii

 
9.B.440.1.3

Putative transport protein of 706 aas and ~ 9 - 11 TMSs in a 5 or 6 TMS cluster (residues 1 - 270) + a 4 or 5 TMSs cluster (residues 490 - 620).

PTP of Theileria parva

 
9.B.440.1.4

Putative transport protein, BMR1, of 668 aas and ~ 14 - 16 TMSs in an apparent 8 + 6 - 8 TMS arrangement.

BMR1 of Babesia microti

 
9.B.440.1.5

Integral membrane protein of 901 aas and ~16 TMSs in an 8 (residues 1 - 270) + 5 (residues 450 - 650) + 3 (residues 700 - 790) TMS arrangement.

IMP of Cryptosporidium abiquitum

 
9.B.440.1.6

NEDD8 ubiquitin conjugation enzyme, Ubc12, of 1198 aas showing regions with similarity with DnaJ homologues and with ubiquitin conjugating enzymes. It may have a strongly hydrophilic N-terminal domain of about 600 residues, followed by a 7 TMS region (residues 601 - 830), followed by 2 TMSs (residues 980 - 1040), followed by 2 more TMSs (residues 1140 - 1180).

Ubc12 of Symbiodinium microadriaticum

 
9.B.440.1.7

Uncharacterized protein of 601 aas and either 10 TMSs (6 + 2 + 2) or 11 (9 + 2) TMSs.

UP of Amoebophrya sp.

 
9.B.440.1.8

Uncharacterized protein of 536 aas and 7 TMSs in a 4 + 3 TMS arrangement. This protein and the other proteins of this size or smaller may be fragments of full sized proteins.

UP of Cardiosporidium cionae