9.B.445.  The Apolipoprotein A2 (ALP-A2) Family 

It may stabilize the HDL (high density lipoprotein) structure by its association with lipids, and thereby affect HDL metabolism.


 

References:

Connolly, K.J., J. Margaria, E. Di Biase, O. Cooper, P.J. Hallett, and O. Isacson. (2023). Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition. Cells 12:.

Di Natale, A., M. Jarau, S.K. Russell, R.A. Horricks, B.N. Lillie, B. Dixon, and J.S. Lumsden. (2019). Rainbow trout Oncorhynchus mykiss (Walbaum) type IV ice-structuring protein LS-12 in the acute-phase response to Flavobacterium psychrophilum infection. J Fish Dis 42: 975-984.

Wang, H., H.C. Zhou, R.L. Ren, S.X. Du, Z.K. Guo, and X.H. Shen. (2022). Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling. Hepatobiliary Pancreat Dis Int. [Epub: Ahead of Print]

Examples:

TC#NameOrganismal TypeExample
9.B.445.1.1

ApoLipoprotein E2 (ApoEII, ApoLP EII) of 100 aas with 1 N-terminal TMS, and possibly one C-terminal TMS. Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling (Wang et al. 2022). It may stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect HDL metabolism.

ApoLP EII of Homo sapiens

 
9.B.445.1.2

ApoLP AII of 100 aas and 1 N-terminal TMS.

ApoLP AII of Zootoca vivipara (common lizard)

 
9.B.445.1.3

Type-4 ice-structuring protein-like of 129 aas and one N-terminal TMS (Di Natale et al. 2019).

Ice-structuring protein of Pygocentrus nattereri (red-bellied piranha)

 
9.B.445.1.4

Apolipoprotein A-II-like protein of 99 aas and 1 N-terminal TMS.

ApoLP AII of Sphaerodactylus townsendi

 
9.B.445.1.5

Embryogenesis regulator of 130 aas and 1 N-terminal TMS.

Embryogenesis regulator of Carassius gibelio (silver crucian carp)

 
9.B.445.1.6

Antifreeze protein type IV of 154 aas and 1 N-terminal TMS.

Antifreeze protein of Epinephelus fuscoguttatus (brown-marbled grouper)

 
9.B.445.1.7

Type-4 ice-structuring protein LS-12-like of 126 aas and 1 N-terminal TMS, possibly with a second TMS at the C-terminus of the protein.

LS-12-like protein of Myxocyprinus asiaticus (Chinese sucker)

 
Examples:

TC#NameOrganismal TypeExample
9.B.445.2.1

Apolipoprotein E, APOE, of 317 aas and 1 TMS.  APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (Krimbou et al. 2004).  It is a core component of plasma lipoproteins and is involved in their production, conversion and clearance, and influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association under physiological conditions (Verghese et al. 2013). APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and it thereby plays an important role in cholesterol homeostasis (Connolly et al. 2023).

APOE of Homo sapiens

 
9.B.445.2.2

Apolipoprotein A-IV, APOA4, of 458 aas and 1 N-terminal TMS.

APOAIV of Carlito syrichta (Philippine tarsier)

 
9.B.445.2.3

Uncharacterized protein of 458 aas and 1 - 3 N-terminal TMSs.

UP of Coryphaenoides rupestris (roundnose grenadier)

 
9.B.445.2.4

Uncharacterized protein of 378 aas with a large peak of hydrophobicity at ~ residue 180 and an apparent internal duplication.

UP of Caranx melampygus (bluefin trevally)

 
9.B.445.2.5

Apolipoprotein A-I isoform X1 of 273 aas and 1 N-terminal TMS.

APOAI isoform X1 of Xenopus tropicalis