9.B.458. The Lipoprotein E (LPOE) Family APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (Krimbou et al. 2004). It is a core component of plasma lipoproteins and is involved in their production, conversion and clearance, and influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association under physiological conditions (Verghese et al. 2013). APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and it thereby plays an important role in cholesterol homeostasis.
References:
Krimbou, L., M. Denis, B. Haidar, M. Carrier, M. Marcil, and J. Genest, Jr. (2004). Molecular interactions between apoE and ABCA1: impact on apoE lipidation. J Lipid Res 45: 839-848.
Verghese, P.B., J.M. Castellano, K. Garai, Y. Wang, H. Jiang, A. Shah, G. Bu, C. Frieden, and D.M. Holtzman. (2013). ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions. Proc. Natl. Acad. Sci. USA 110: E1807-1816.