9.B.469.  The Apoptosis-inducing Factor, Mitochondria-associated 1 (AIFM1) Family

It functions both as an NADH oxidoreductase and a regulator of apoptosis (Ghezzi et al. 2010). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway.


 

References:

Ghezzi, D., I. Sevrioukova, F. Invernizzi, C. Lamperti, M. Mora, P. D''Adamo, F. Novara, O. Zuffardi, G. Uziel, and M. Zeviani. (2010). Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor. Am J Hum Genet 86: 639-649.
Shi, M., N. Zhou, M. Xiu, X. Li, F. Shan, W. Chen, W. Li, C.M. Chiang, X. Wu, Y. Zhang, A. Li, and J. Cao. (2024). Identification of host proteins that interact with African swine fever virus pE301R. Eng Microbiol 4: 100149.
Examples:

TC#NameOrganismal TypeExample
9.B.469.1.1

 The apoptosis-inducing factor, mitochondria-associated 1 (AIFM1) protein of 613 aas possibly with as many as 4 TMSs, one near the N-terminus, one at about residue 80, another at about residue 130, another at about residue 500, and a fourth at the C-terminus.  It is a regulator of apoptosis (Shi et al. 2024).

AIFM1 of Homo sapiens

 
9.B.469.1.2

AIFM1 of 613 aas; 95% identical to the human ortholog.  This is the protein in pig that interacts with the African swine fever virus pE301R (Shi et al. 2024).

AIFM1 of Sus scrofa

 
9.B.469.1.3

Apoptosis inducing factor mitochondria associated 1, AIFM1, of 613 aas.

AIFM1 of Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)