9.B.55 The 4 TMS DUF307/YccF (DUF307) Family 

This family includes the E. coli YccF 4 TMS protein of unknown function.  This domain contains two 2 TMSs repeated in tandem. This 2 TMS domain is found in some calcium:cation antiporters of the CaCA family.  These proteins have TC#s 2.A.19.7.1 &2. 


TC#NameOrganismal TypeExample

The small 4 TMS protein, YccF of 148 aas and 4 putative TMSs.

YccF of E. coli


Uncharacterized DUF307 homologue of 131 aas and 4 TMS in a tandem 2 TMS repeated arrangement.  Homologous to a 2 TMS N-terminal sequence in the CaCA family protein with TC# 2.A.19.7.1 & 2.

UP of Mycobacterium phlei (Mycobacterium smegmatis)


Uncharacterized protein of 193 aas and 4 TMSs.

UP of Chlorella variabilis (Green alga)


TC#NameOrganismal TypeExample

Uncharacterized protein of 145 aas with two adjacent 2 TMS DUF307 domains.

UP of Perkinsus marinus


Uncharacterized protein of 313 aas with a C-terminal DUF375 domain of 4 putative TMSs, and a hydrophilic N-terminal domain with a long QPAG rich region of unknown function.

UP of Trichoplax adhaerens (Trichoplax reptans)