9.B.66 The Propionicin PLG-1 (Propionicin PLC-1) Family 

Propionicin PLG-1 is a bacteriocin produced by Propionibacterium thoenii P127. This  bacteriocin inhibits wide range of food-borne pathogens such as Escherichia coli, Pseudomonas aeruginosa, Vibrio parahaemolyticus, Yersinia enterocolitica, Listeria monocytogenes and a strain of Corynebacterium sp. The plg-1 gene expressing propionicin PLG-1 was transformed into various lactic acid bacteria and showed antimicrobial activity against the pathogens cited above.  It can therefore be used in probiotic bacteria to combat pathogens (Mohamed and Tahoun 2015).



Mohamed, S.E. and M.K. Tahoun. (2015). The expression of propionicin PLG-1 gene (plg-1) by lactic starters. J Dairy Res 82: 209-214.


TC#NameOrganismal TypeExample

Propionicin PLG-1, or Pig-1 of 99 aas and 3 TMSs.  It is an effective antimicrobial agent against several pathogens when expressed in various lactic acid bacteria (Mohamed and Tahoun 2015).

Pig1 of Propionibacterium thoenii


Protease-activated antimicrobial peptide,PamA, of 225 aas and 3 TMSs, one N-terminal and two C-terminal.

PamA of Propionibacterium jensenii


Uncharacterized protein of 183 aas and 1 - 3 TMSs

UP of Devriesea agamarum


TC#NameOrganismal TypeExample

Uncharacterized protein of 275 aas and 3 TMSs, 1 at the N-terminus and two at the C-terminus.

UP of Nocardia nova


Uncharacterized protein of 224 aas and 3 TMSs.

UP of Rhodococcus ruber


Uncharacterized protein of 199 aas and 3 TMSs.

UP of Rhodococcus triatomae


Uncharacterized protein of 240 aas and 2 TMSs.

UP of Nocardia nova