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9.B.75 The Ethanol Utilization/Transport (Eut) Protein Family
This family includes several proteins of various lengths that have been implicated in ethanol metabolism. One of these is EutQ (233 aas; pfam06249; COG4766), annotated as being involved in ethanol utilization. It is an aceetate kinase, not a transporter (Moore and Escalante-Semerena 2016). This family may include Cupin2 of Burkholderia phymatum (147 aas; gi#11827465), WhiEII of Streptomyces coelicolor (157 aas; P23157) concerned with pigmentation, and Orf116 of Arthobacter nicotinovorans (116 aas), but these proteins are distanly related to each other if at all. Homology has not been established, and none of them may have TMSs.
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| References: |
Baitsch, D., C. Sandu, R. Brandsch, and G.L. Igloi. (2001). Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase. J. Bacteriol. 183: 5262-5267.
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Brandsch, R. (2006). Microbiology and biochemistry of nicotine degradation. Appl. Microbiol. Biotechnol. 69: 493-498.
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Moore, T.C. and J.C. Escalante-Semerena. (2016). The EutQ and EutP proteins are novel acetate kinases involved in ethanolamine catabolism: physiological implications for the function of the ethanolamine metabolosome in Salmonella enterica. Mol. Microbiol. 99: 497-511.
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| Examples: |
| TC# | Name | Organismal Type | Example |
| 9.B.75.1.1 | Putative efflux porter, Orf116 (Duf861; Pfam05899 family) | Bacteria | Orf116 of Arthrobacter nicotinovorans (AAK64251) |
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| Examples: |
| TC# | Name | Organismal Type | Example |
| 9.B.75.2.1 | Ethanol utilization; acetate kinase, EutQ (COG4766; Pfam06249). It is homologous and similar in sequence to the Salmonella orthologous acetate kinases, EutQ and EutP (Moore and Escalante-Semerena 2016). | Bacteria | EutQ of E. coli (233 aas; gi#15832576) |
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| Examples: |
| TC# | Name | Organismal Type | Example |
| 9.B.75.3.1 | Cupin 2
| Bacteria | Cupin 2 of Burkholderia phymatum (147 aas; B2JQU6) |
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| Examples: |
| TC# | Name | Organismal Type | Example |
| 9.B.75.4.1 | WhiEII pigmentation protein | Bacteria | WhiEII of Streptomyces coelicolor (157 aas; P23157) |
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