9.B.79 The Putative Metal Transporter (PmtA) Family

In Streptococcus pyogenes, the PerR-regulated pmtA gene encoding the PerR-regulated putative metal transporter, contributed to resistance against peroxide stress. pmtA may function to link metal homeostasis and oxidative stress responses (Brenot et al., 2007).

PmtR (161 aas; 4 putative TMSs) shows sequence similarity (residues 25-65 shows 43% identity with residues 44-81) with the Synechocystis Na+/H+ exchanger TC# 2.A.36.7.2). However, no homologues are found outside of S. pyogenes.

The reaction believed to be catalyzed by PmtA is:

Metal (out) Metal (in).



Brenot, A., B.F. Weston, and M.G. Caparon. (2007). A PerR-regulated metal transporter (PmtA) is an interface between oxidative stress and metal homeostasis in Streptococcus pyogenes. Mol. Microbiol. 63: 1185-1196.


TC#NameOrganismal TypeExample
9.B.79.1.1The PmtA protein (putative metal transporter) BacteriaPmtA of Streptococcus pyogenes (Q99Z25)