9.B.81 The MceB Immunity Protein (MceB) Family

The MceB protein of Klebsiella pneumoniae protects the cells against the toxic endogenous MceE protein, the precursor of microcin E492, and against this exogenous microcin (Bieler et al., 2006; Lagos et al., 1999; 2001). Its mechanism of action is not known, but it is a cytoplasmic membrane protein with three putative TMSs.



Lagos, R., J.E. Villanueva, and O. Monasterio. (1999). Identification and properties of the genes encoding microcin E492 and its immunity protein. J. Bacteriol. 181: 212-217.

Bieler, S., F. Silva, C. Soto, and D. Belin. (2006). Bactericidal activity of both secreted and nonsecreted microcin E492 requires the mannose permease. J. Bacteriol. 188: 7049-7061.

Lagos, R., M. Baeza, G. Corsini, C. Hetz, E. Strahsburger, J.A. Castillo, C. Vergara, and O. Monasterio. (2001). Structure, organization and characterization of the gene cluster involved in the production of microcin E492, a channel-forming bacteriocin. Mol. Microbiol. 42: 229-243.


TC#NameOrganismal TypeExample
9.B.81.1.1The MceB immunity protein (protects against MceE and microcin E492)BacteriaMceB of Klebsiella pneumoniae (Q9ZHG0)