TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.E.8.1.1









Lysis protein, T, of 218 aas and 1 TMS. T holin activity is regulated by the largely periplasmic anti-holin RI (P13304) and the cytoplasmic antiholin RIII which act synergistically (Chen and Young 2016). RI is degraded by DegP (Tran et al., 2007).  Mutations in all 3 topological domains if RI (the N-terminal cytoplasmic domain, the single TMS, and the C-terminal periplasmic domain) can abrogate holin function (Moussa et al. 2014).

Viruses
Caudovirales
Lysis protein or holin (P06808) of Phage T4
*1.E.8.1.2









T-holin (196 aas) of phage RB43.

Viruses
Caudovirales
T-holin of phage RB43
*1.E.8.1.3









Putative holin of 208 aas and 1 TMS.

Viruses
Caudovirales
Holin of pectobacterial phage My1
*1.E.8.1.4









Putative holin (lysis protein) of enterobacterial phage T5 (218 aas; 1 TMS) (Catalão et al. 2012).

Viruses
Caudovirales
Putative holin of phage T5
*1.E.8.1.5









T holin lysis mediator of 215 aas and 1 TMS.  Phage KP27 protects against multidrug resistant strains of Klebsiella (Maciejewska et al. 2016).

Viruses
Caudovirales
Holin of Klebsiella phage KP27