TCDB is operated by the Saier Lab Bioinformatics Group

Calculation of Protein Properties

  • Hydropathy Analysis - Hydropathy analysis using the Kyte-Doolittle scale combined with hydrophobic moment and TMS prediction.
  • EMBOSS Pepwindow - EMBOSS Hydropathy Analysis
  • EMBOSS Hmoment - EMBOSS Hmoment calculates the hydrophobic moment, the hydrophobicity of a peptide measured for a specified angle of rotation per residue.
  • EMBOSS Pepwheel - creates a helical wheel plot that displays a protein sequence looking down the axis of the alpha helix. This view facilitates the identification of amphipathic TMSs.
  • Helixator - creates a helical wheel plot that displays a protein sequence looking down the axis of the alpha helix. This view facilitates the identification of amphipathic TMSs.
  • HMMTOP - Highlight TMS regions in a protein as predicted by HMMTOP
  • TMSTATS - Statistical analysis of topological data within any TC hierarchy, domain, or phyla
  • Length Statistics - Statistical analysis of protein lengths within any TC hierarchy, domain, or phyla

Sequence Similarity Search

  • BLAST - Search against TC-DB with a protein or nucleotide sequence.
  • PSIBLAST - Search TC-DB for distant homologs

Pairwise Sequence Alignment

Multiple Sequence Alignment Tools and Accessories

Other Sequence Analysis Tools