TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.108.1:  The Oxidase-dependent Fe2+ Transporter (OFeT) Family
*2.A.108.1.1









High-affinity oxidase-dependent plasma membrane Fe2+-Fe3+ uptake transporter, Ftr1 of 404 aas and 7 TMSs in a 3. + 3 + 1 arrangement. May be a "transceptor", combining transport and receptor functions (Diallinas 2017).

Eukaryota
Fungi
Fet3 and Ftr1 of Saccharomyces cerevisiae
Fet3 (aka Fet3p) (multicopper ferrooxidase)
Ftr1 (Fe3+ transporter)
*2.A.108.1.2









Iron-repressible Fe2+ uptake porter, FTR1 (Ziegler et al. 2011)

Eukaryota
Fungi
Ftr1 of Candida albicans
*2.A.108.1.3









Iron-inducible Fe2+ uptake porter, FTR2
Eukaryota
Fungi
Ftr2 of Candida albicans
*2.A.108.1.4









High-affinity oxidase-dependent vacuolar Fe2+-Fe3+ uptake transporter (Singh et al. 2006)

Eukaryota
Fungi
Fet5p and Fth1p of Saccharomyces cerevisiae
Fet5p (multicopper ferrooxidase) (NP_116612)
Fth1p (Fe3+ transporter) (NP_009766)
*2.A.108.1.5









High-affinity oxidase-dependent plasma membrane Fe2+-Fe3+ uptake transporter (Singh et al., 2006)

Eukaryota
Fungi
Fio1 and Fip1 of Schizosaccharomyces pombe
Fio1 (multicopper ferrooxidase) (Q09920)
Fip1 (Fe3+ transporter) (Q09919
*2.A.108.1.6









Iron transporter, Ftr1 (541 aas) (La Fontaine et al., 2002). FTR1, like its orthologue in S. cerevisiae (9.A.10.1.1), has an exocytoplasmic iron channeling motif and two potential iron permeation motifs in membrane-spanning regions (Terzulli and Kosman 2010).

Eukaryota
Viridiplantae
Ftr1 of Chlamydomonas reinhardtii (AAM45938)
*2.A.108.1.7









The Ftr1/Fet3 high-affinity iron uptake system (Larrondo et al., 2007)
Eukaryota
Fungi
Ftr1/Fet3 of Phanerochaete chrysosporium
Ftr1 (Q1P9T0)
Fet3 (Q1P9T1)
*2.A.108.1.8









High affinity iron permease, CaFtr1 (Jung et al. 2008)

Eukaryota
Fungi
CaFtr1 of Cryptococcus neoformans (Q5KJQ5)
*2.A.108.2.1









The lead (Pb2+) uptake porter, PbrT
Bacteria
Proteobacteria
PbrT of Ralstonia metallidurans CH34 (gbCAC28871)
*2.A.108.2.2









The high-affinity oxidase-dependent iron transporter, FTR-ChpA

Bacteria
Proteobacteria
FTR-ChpA of Brucella melitensis
FTR (AAL54125)
*2.A.108.2.3









The acid-induced, low pH, ferrous iron (Fe2+) uptake transporter, EfeUOB (YcdN); cryptic in E. coli K12 (Cao et al. 2007; Grosse et al., 2006)

Bacteria
Proteobacteria
EfeUOB of E. coli O157:H5
EfeU - P75901
EfeO (periplasmic cupredoxin domain containing protein) - P0AB24
EfeB (peroxidase) - P31545
*2.A.108.2.4









The Ftr1 (integral membrane transporter)/ P19 (periplasmic iron binding protein) iron uptake system. P19 has distinct copper and iron binding sites and exhibits an immunoglobulin-like fold (Chan et al., 2010).

Bacteria
Proteobacteria
Ftr1/P19 of Campylobacter jejuni
Ftr1 (Q5HSD5)
P19 (Q0P7X0)
*2.A.108.2.5









Ferrous iron uptake permease, EfeU

Bacteria
Firmicutes
EfeU of Bacillus subtilis
*2.A.108.2.6









High affinity Fe2+/Pb2+ permease-like protein.

Bacteria
Thermobaculum
Permease of Thermobaculum terrenum
*2.A.108.2.7









Pb2+ uptake porter of 643 aas, PbtT or FTR1 (HloĹžková et al. 2013).

Bacteria
Proteobacteria
PbtT of Achromobacter xylosoxidans
*2.A.108.2.8









Ftr1 protein of 276 aas and 8 TMSs

Archaea
Crenarchaeota
Ftr1 protein of Aeropyrum pernix
*2.A.108.2.9









Siderophore-independent iron uptake porter, FtrCAB:  FtrC (280 aas, 7 TMSs)/FtrA (183 aas; 1 TMS)/FtrB (110 aas, 0 TMSs) (Mathew et al. 2014).  Functions with FtrD, an iron-sulfur cluster-containing ferredoxin of 465 aas.

Bacteria
Proteobacteria
FtrCAB of Burkholderia cenocepacia
*2.A.108.2.10









Dipartite iron uptake system, FetM (646 aas; 8 TMSs in a 1 +  7 TMS arrangement)/FetP (a periplasmic protein that enhances iron uptake by FetM) (Koch et al. 2011).  FetP binds Cu2+ and Mn2+ at two different sites, 1.3 Å apart, in this homodimeric protein, and the 3-d structure with Cu2+ bound to each of the two subunits reveals different geometries at the two sites. FetMP may be an iron permease with an iron scavenging function, and possibly also an iron reducing function (Koch et al. 2011).

Bacteria
Proteobacteria
FetMP of E. coli
*2.A.108.2.11









Putative heavy metal transporter, Ftr1/Tp34 or Tpd, (TP0972/TP0971).  Ftr1 has 448 aas with 9 TMSs while Tp34 has 204 aas with 1 N-terminal TMSs. This antigen is a pathogen-specific membrane immunogen. This periplasmic dimeric protein binds human lactoferrin with submicromolar affinity with a stoichiometry of 2:1 (Deka et al. 2007).  It's 3-d structure (1.9 Å resolution) reveals two metal binding sites per monomer with zinc bound to both sites (Deka et al. 2007).

Ftr1/Tdp of Treponema pallidum
*2.A.108.3.1









Hypothetical protein of 208 aas

Archaea
Crenarchaeota
HP of Sulfolobus islandicus
*2.A.108.3.2









Manganese ion transporter, MntH of 250 aas and 6 - 7 TMSs.

Bacteria
Proteobacteria
MntH of Rhizobium leguminosarum
*2.A.108.3.3









Hypothetical protein

Archaea
Crenarchaeota
HP of Sulfolobus acidocaldarius