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2.A.3.8.21
Asc-type amino acid transporter 1 (Asc-1) (Solute carrier family 7 member 10)

Accession Number:Q9NS82
Protein Name:Asc-type amino acid transporter 1
Length:523
Molecular Weight:56798.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: Q9NS82
eggNOG: COG0531
HEGENOM: HOG000098892
Entrez Gene ID: 56301   
KEGG: hsa:56301   

Gene Ontology

GO:0030425 C:dendrite
GO:0005887 C:integral to plasma membrane
GO:0015194 F:L-serine transmembrane transporter activity
GO:0007596 P:blood coagulation
GO:0042941 P:D-alanine transport
GO:0042942 P:D-serine transport
GO:0006811 P:ion transport
GO:0050900 P:leukocyte migration

References (4)

[1] “Cloning and characterization of a human brain Na+-independent transporter for small neutral amino acids that transports D-serine with high affinity.”  Nakauchi J.et.al.   10863037
[2] “Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria?”  Leclerc D.et.al.   11509015
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGHTQQPSG RGNPRPAPSP SPVPGTVPGA SERVALKKEI GLLSACTIII GNIIGSGIFI 
61:	SPKGVLEHSG SVGLALFVWV LGGGVTALGS LCYAELGVAI PKSGGDYAYV TEIFGGLAGF 
121:	LLLWSAVLIM YPTSLAVISM TFSNYVLQPV FPNCIPPTTA SRVLSMACLM LLTWVNSSSV 
181:	RWATRIQDMF TGGKLLALSL IIGVGLLQIF QGHFEELRPS NAFAFWMTPS VGHLALAFLQ 
241:	GSFAFSGWNF LNYVTEEMVD ARKNLPRAIF ISIPLVTFVY TFTNIAYFTA MSPQELLSSN 
301:	AVAVTFGEKL LGYFSWVMPV SVALSTFGGI NGYLFTYSRL CFSGAREGHL PSLLAMIHVR 
361:	HCTPIPALLV CCGATAVIML VGDTYTLINY VSFINYLCYG VTILGLLLLR WRRPALHRPI 
421:	KVNLLIPVAY LVFWAFLLVF SFISEPMVCG VGVIIILTGV PIFFLGVFWR SKPKCVHRLT 
481:	ESMTHWGQEL CFVVYPQDAP EEEENGPCPP SLLPATDKPS KPQ