TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.3.8.23
Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2).  Transports certain thyroid hormones and their derivatives as well as multiple amino acids(Krause and Hinz 2017).

Accession Number:Q92536
Protein Name:Y+L amino acid transporter 2
Length:515
Molecular Weight:56828.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate Amino acids, Thyroid hormones, thyroid hormone derivatives

Cross database links:

Genevestigator: Q92536
eggNOG: COG0531
HEGENOM: HOG000098892
Entrez Gene ID: 9057   
KEGG: hsa:9057   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0015297 F:antiporter activity
GO:0007596 P:blood coagulation
GO:0006520 P:cellular amino acid metabolic process
GO:0006811 P:ion transport
GO:0050900 P:leukocyte migration
GO:0006461 P:protein complex assembly

References (14)

[1] “Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.”  Torrents D.et.al.   9829974
[2] “Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.”  Nagase T.et.al.   9039502
[3] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects.”  Dall'Asta V.et.al.   11078698
[6] “The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.”  Broeer A.et.al.   10903140
[7] “Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.”  Broeer A.et.al.   11311135
[8] “Two-way arginine transport in human endothelial cells: TNF-alpha stimulation is restricted to system y(+).”  Sala R.et.al.   11742806
[9] “Nitric oxide synthesis requires activity of the cationic and neutral amino acid transport system y+L in human umbilical vein endothelium.”  Arancibia-Garavilla Y.et.al.   14603368
[10] “INFgamma stimulates arginine transport through system y+L in human monocytes.”  Rotoli B.M.et.al.   15280038
[11] “A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance.”  Sperandeo M.P.et.al.   15756301
[12] “Mutation of the 4F2 heavy-chain carboxy terminus causes y+ LAT2 light-chain dysfunction.”  Chubb S.et.al.   16785209
[13] “Activation of classical protein kinase C decreases transport via systems y+ and y+L.”  Rotmann A.et.al.   17329401
[14] “Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells.”  Kaneko S.et.al.   17197568

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MEAREPGRPT PTYHLVPNTS QSQVEEDVSS PPQRSSETMQ LKKEISLLNG VSLVVGNMIG 
61:	SGIFVSPKGV LVHTASYGMS LIVWAIGGLF SVVGALCYAE LGTTITKSGA SYAYILEAFG 
121:	GFIAFIRLWV SLLVVEPTGQ AIIAITFANY IIQPSFPSCD PPYLACRLLA AACICLLTFV 
181:	NCAYVKWGTR VQDTFTYAKV VALIAIIVMG LVKLCQGHSE HFQDAFEGSS WDMGNLSLAL 
241:	YSALFSYSGW DTLNFVTEEI KNPERNLPLA IGISMPIVTL IYILTNVAYY TVLNISDVLS 
301:	SDAVAVTFAD QTFGMFSWTI PIAVALSCFG GLNASIFASS RLFFVGSREG HLPDLLSMIH 
361:	IERFTPIPAL LFNCTMALIY LIVEDVFQLI NYFSFSYWFF VGLSVVGQLY LRWKEPKRPR 
421:	PLKLSVFFPI VFCICSVFLV IVPLFTDTIN SLIGIGIALS GVPFYFMGVY LPESRRPLFI 
481:	RNVLAAITRG TQQLCFCVLT ELDVAEEKKD ERKTD