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8.A.18.3.1
Ca2+ channel, voltage-dependent, α2δ subunit 3, CACNA2D3 of 1091 aas and 2 - 4 TMSs (Baeza-Richer et al. 2015).

Accession Number:Q8IZS8
Protein Name:CACNA2D3
Length:1091
Molecular Weight:123011.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q8IZS8
eggNOG: prNOG12030
HEGENOM: HBG402807
RefSeq: NP_060868.2   
Entrez Gene ID: 55799   
Pfam: PF02743    PF00092    PF08399   
Drugbank: Drugbank Link   
OMIM: 606399  gene
KEGG: hsa:55799   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0046872 F:metal ion binding
GO:0006816 P:calcium ion transport

References (4)

[1] “Cloning a calcium channel alpha2delta-3 subunit gene from a putative tumor suppressor gene region at chromosome 3p21.1 in conventional renal cell carcinoma.”  Hanke S.et.al.   11245980
[2] “Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.”  Qin N.et.al.   12181424
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes.”  Gong H.C.et.al.   11687876

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGPGSPRRA SRGASALLAA ALLYAALGDV VRSEQQIPLS VVKLWASAFG GEIKSIAAKY 
61:	SGSQLLQKKY KEYEKDVAIE EIDGLQLVKK LAKNMEEMFH KKSEAVRRLV EAAEEAHLKH 
121:	EFDADLQYEY FNAVLINERD KDGNFLELGK EFILAPNDHF NNLPVNISLS DVQVPTNMYN 
181:	KDPAIVNGVY WSESLNKVFV DNFDRDPSLI WQYFGSAKGF FRQYPGIKWE PDENGVIAFD 
241:	CRNRKWYIQA ATSPKDVVIL VDVSGSMKGL RLTIAKQTVS SILDTLGDDD FFNIIAYNEE 
301:	LHYVEPCLNG TLVQADRTNK EHFREHLDKL FAKGIGMLDI ALNEAFNILS DFNHTGQGSI 
361:	CSQAIMLITD GAVDTYDTIF AKYNWPDRKV RIFTYLIGRE AAFADNLKWM ACANKGFFTQ 
421:	ISTLADVQEN VMEYLHVLSR PKVIDQEHDV VWTEAYIDST LPQAQKLTDD QGPVLMTTVA 
481:	MPVFSKQNET RSKGILLGVV GTDVPVKELL KTIPKYKLGI HGYAFAITNN GYILTHPELR 
541:	LLYEEGKKRR KPNYSSVDLS EVEWEDRDDV LRNAMVNRKT GKFSMEVKKT VDKGKRVLVM 
601:	TNDYYYTDIK GTPFSLGVAL SRGHGKYFFR GNVTIEEGLH DLEHPDVSLA DEWSYCNTDL 
661:	HPEHRHLSQL EAIKLYLKGK EPLLQCDKEL IQEVLFDAVV SAPIEAYWTS LALNKSENSD 
721:	KGVEVAFLGT RTGLSRINLF VGAEQLTNQD FLKAGDKENI FNADHFPLWY RRAAEQIPGS 
781:	FVYSIPFSTG PVNKSNVVTA STSIQLLDER KSPVVAAVGI QMKLEFFQRK FWTASRQCAS 
841:	LDGKCSISCD DETVNCYLID NNGFILVSED YTQTGDFFGE IEGAVMNKLL TMGSFKRITL 
901:	YDYQAMCRAN KESSDGAHGL LDPYNAFLSA VKWIMTELVL FLVEFNLCSW WHSDMTAKAQ 
961:	KLKQTLEPCD TEYPAFVSER TIKETTGNIA CEDCSKSFVI QQIPSSNLFM VVVDSSCLCE 
1021:	SVAPITMAPI EIRYNESLKC ERLKAQKIRR RPESCHGFHP EENARECGGA PSLQAQTVLL 
1081:	LLPLLLMLFS R