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Accession Number: | P23945 |
Protein Name: | Follicle-stimulating hormone receptor |
Length: | 695 |
Molecular Weight: | 78265.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
Cross database links:
Entrez Gene ID: | 2492 |
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Pfam: | PF00001 PF12369 PF01462 |
KEGG: | hsa:2492 hsa:2492 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0004963
F:follicle-stimulating hormone receptor activity
GO:0005515
F:protein binding
GO:0007292
P:female gamete generation
GO:0008584
P:male gonad development
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References (54)[1] “Cloning and sequencing of human FSH receptor cDNA.” Minegish T.et.al. 1709010 [2] “Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts.” Tilly J.L.et.al. 1322283 [3] “The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells.” Kelton C.A.et.al. 1301382 [4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [5] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.” Hillier L.W.et.al. 15815621 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor.” Gromoll J.et.al. 1359889 [8] “Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene.” Gromoll J.et.al. 7926278 [9] “Localization of the human FSH receptor to chromosome 2p21 using a genomic probe comprising exon 10.” Gromoll J.et.al. 7916967 [10] “Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.” Jiang X.et.al. 8747461 [11] “Structure of human follicle-stimulating hormone in complex with its receptor.” Fan Q.R.et.al. 15662415 [12] “Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure.” Aittomaeki K.et.al. 7553856 [13] “A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors.” Kotlar T.J.et.al. 9100567 [14] “An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man.” Gromoll J.et.al. 8636335 [15] “The frequency of an inactivating point mutation (566C-->T) of the human follicle-stimulating hormone receptor gene in four populations using allele-specific hybridization and time-resolved fluorometry.” Jiang M.et.al. 9851774 [16] “A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor.” Beau I.et.al. 9769327 [17] “New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype.” Touraine P.et.al. 10551778 [18] “Characterization of single-nucleotide polymorphisms in coding regions of human genes.” Cargill M.et.al. 10391209 [19] “Distribution and function of FSH receptor genetic variants in normal men.” Asatiani K.et.al. 12059813 [20] “A novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure.” Doherty E.et.al. 11889179 [21] “A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics.” Allen L.A.et.al. 12571157 [22] “Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological, and molecular studies.” Meduri G.et.al. 12915623 [23] “A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome.” Vasseur C.et.al. 12930927 [24] “Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor.” Smits G.et.al. 12930928 [25] “A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome.” Montanelli L.et.al. 15080154 [26] “Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology.” De Leener A.et.al. 16278261 [27] “Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome.” De Leener A.et.al. 17721928 [28] “Cloning and sequencing of human FSH receptor cDNA.” Minegish T.et.al. 1709010 [29] “Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts.” Tilly J.L.et.al. 1322283 [30] “The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells.” Kelton C.A.et.al. 1301382 [31] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [32] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.” Hillier L.W.et.al. 15815621 [33] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [34] “Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor.” Gromoll J.et.al. 1359889 [35] “Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene.” Gromoll J.et.al. 7926278 [36] “Localization of the human FSH receptor to chromosome 2p21 using a genomic probe comprising exon 10.” Gromoll J.et.al. 7916967 [37] “Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.” Jiang X.et.al. 8747461 [38] “Structure of human follicle-stimulating hormone in complex with its receptor.” Fan Q.R.et.al. 15662415 [39] “Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure.” Aittomaeki K.et.al. 7553856 [40] “A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors.” Kotlar T.J.et.al. 9100567 [41] “An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man.” Gromoll J.et.al. 8636335 [42] “The frequency of an inactivating point mutation (566C-->T) of the human follicle-stimulating hormone receptor gene in four populations using allele-specific hybridization and time-resolved fluorometry.” Jiang M.et.al. 9851774 [43] “A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor.” Beau I.et.al. 9769327 [44] “New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype.” Touraine P.et.al. 10551778 [45] “Characterization of single-nucleotide polymorphisms in coding regions of human genes.” Cargill M.et.al. 10391209 [46] “Distribution and function of FSH receptor genetic variants in normal men.” Asatiani K.et.al. 12059813 [47] “A novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure.” Doherty E.et.al. 11889179 [48] “A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics.” Allen L.A.et.al. 12571157 [49] “Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological, and molecular studies.” Meduri G.et.al. 12915623 [50] “A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome.” Vasseur C.et.al. 12930927 [51] “Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor.” Smits G.et.al. 12930928 [52] “A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome.” Montanelli L.et.al. 15080154 [53] “Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology.” De Leener A.et.al. 16278261 [54] “Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome.” De Leener A.et.al. 17721928
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Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MALLLVSLLA FLSLGSGCHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE LRFVLTKLRV 61: IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI RIEKANNLLY INPEAFQNLP 121: NLQYLLISNT GIKHLPDVHK IHSLQKVLLD IQDNINIHTI ERNSFVGLSF ESVILWLNKN 181: GIQEIHNCAF NGTQLDELNL SDNNNLEELP NDVFHGASGP VILDISRTRI HSLPSYGLEN 241: LKKLRARSTY NLKKLPTLEK LVALMEASLT YPSHCCAFAN WRRQISELHP ICNKSILRQE 301: VDYMTQARGQ RSSLAEDNES SYSRGFDMTY TEFDYDLCNE VVDVTCSPKP DAFNPCEDIM 361: GYNILRVLIW FISILAITGN IIVLVILTTS QYKLTVPRFL MCNLAFADLC IGIYLLLIAS 421: VDIHTKSQYH NYAIDWQTGA GCDAAGFFTV FASELSVYTL TAITLERWHT ITHAMQLDCK 481: VQLRHAASVM VMGWIFAFAA ALFPIFGISS YMKVSICLPM DIDSPLSQLY VMSLLVLNVL 541: AFVVICGCYI HIYLTVRNPN IVSSSSDTRI AKRMAMLIFT DFLCMAPISF FAISASLKVP 601: LITVSKAKIL LVLFHPINSC ANPFLYAIFT KNFRRDFFIL LSKCGCYEMQ AQIYRTETSS 661: TVHNTHPRNG HCSSAPRVTN GSTYILVPLS HLAQN