| Transporter Information: | |
| Name: | solute carrier family 25, member 28 |
|---|---|
| Symbol: | SLC25A28 |
| TC: | 2.A.29.5.2 |
| Locations: | 10q24 |
| Aliases: | MRS3/4 |
| GenBank: | AF327402 |
| Swiss-Prot: | Q96A46 |
| Accession Number: | NM_031212 |
| LocusLink | 81894 |
| PubMed (11297739): | Li FY, Nikali K, Gregan J, Leibiger I, Leibiger B, Schweyen R, Larsson C,Suomalainen A. Characterization of a novel human putative mitochondrial transporter homologousto the yeast mitochondrial RNA splicing proteins 3 and 4.FEBS Lett. 2001 Apr 6;494(1-2):79-84. PMID: 11297739 [PubMed - indexed for MEDLINE] We report here a novel human gene, hMRS3/4, encoding a putative mitochondrial transporter structurally and functionally homologous to the yeast mitochondrial RNA splicing proteins 3 and 4. These proteins belong to the family of mitochondrial carrier proteins (MCF) and are likely to function as solute carriers. hMRS3/4 spans approximately 10 kb of genomic DNA on chromosome 10q24 and consists of four exons that encode a 364-aa protein with six transmembrane domains. A putative splice variant, encoding a 177-aa protein with three transmembrane domains, was also identified. hMRS3/4 has a well-conserved signature sequence of MCF and is targeted into the mitochondria. When expressed in yeast, hMRS3/4 efficiently restores the mitochondrial functions in mrs3(o)mrs4(o) knock-out mutants. Ubiquitous expression in human tissues and a well-conserved structure and function suggest an important role for hMRS3/4 in human cells. |
>sp|Q96A46|MFRN2_HUMAN Mitoferrin-2 OS=Homo sapiens GN=SLC25A28 PE=2 SV=1 MELEGRGAGGVAGGPAAGPGRSPGESALLDGWLQRGVGRGAGGGEAGACRPPVRQDPDSGPDYEALPAGATVTTHMVAGA VAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLS DVIHPGGNSHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQA IHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGG VTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEWRAGK | |