3.A.1.134.7
The VraFG ABC transporter interacts with GraXSR [GraX, Q7A2W7; GraS, A6QEW9; GraR, A6QEW8] to form a five- or six-component system required for cationic antimicrobial peptide sensing and resistance (Falord et al., 2012). VraX has been termed a two component system connector and may not be a component of the transporter. VraFG may be a sensor rather than the transporter for the substrate peptide. The actual transporter regulated by VraFGX may have TC# 4.H.1.1.1 (MprF) (Falord et al. 2012). The extracellular loop of the membrane permease VraG interacts with GraS to sense cationic antimicrobial peptides in Staphylococcus aureus (Cho et al. 2021).
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| Accession Number: | A6QEX1 |
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| Protein Name: | ABC-type transport system permease component VraG |
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| Length: | 633 |
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| Molecular Weight: | 72161.00 |
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| Species: | Staphylococcus aureus (strain Newman) [426430] |
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| Number of TMSs: | 10 |
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| Substrate |
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1: MALIMTFNEI IFKNFRQNLS HYAIYLFSLI TSVVLYFSFV ALKYAHKLNM TESYPIIKEG
61: SQVGSYFLFF IIIAFLLYAN VLFIKRRSYE LALYQTLGLS KFNIIYILML EQLLIFIITA
121: ILGIIIGIFG SKLLLMIVFT LLGIKEKVPI IFSLRAVFET LMLIGVAYFL TSAQNFILVF
181: KQSISQMSKN NQVKETNHNK ITFEEVVLGI LGIVLITTGY YLSLNIVQYY DSIGTLMFIL
241: LSTVIGAYLF FKSSVSLVFK MVKKFRKGVI SVNDVMFSSS IMYRIKKNAF SLTVMAIISA
301: ITVSVLCFAA ISRASLSSEI KYTAPHDVTI KDQQKANQLA SELNNQKIPH FYNYKEVIHT
361: KLYKDNLFDV KAKEPYNVTI TSDKYIPNTD LKRGQADLFV AEGSIKDLVK HKKHGKAIIG
421: TKKHHVNIKL RKDINKIYFM TDVDLGGPTF VLNDKDYQEI RKYTKAKHIV SQFGFDLKHK
481: KDALALEKAK NKVDKSIETR SEAISSISSL TGILLFVTSF LGITFLIAVC CIIYIKQIDE
541: TEDELENYSI LRKLGFTQKD MARGLKFKIM FNFGLPLVIA LSHAYFTSLA YMKLMGTTNQ
601: IPVFIVMGLY ICMYAVFAVT AYNHSKRTIR HSI