4.A.2.1.28
Nitrogen regulatory phosphoryl transfer chain, E1Ntr - NPr - IIANtr consisting of three cytolasmic phosphoryl transfer proteins as indicated: E1Ntr, PtsP, Enzyme 1-like protein of 759 aas; - NPN in Pseudomonas aeruginosa is phosphorylated by redundant upstream proteins and impacts virulence-related genes (Underhill et al. 2023). The bacterial nitrogen-related phosphotransfer (PTSNtr) system bears homology to PTS systems that facilitate saccharide import and phosphorylation. It influences expression of genes involved in type III secretion, potassium transport, and pyoverdine biosynthesis as well as biofilm formation and virulence (Underhill et al. 2023). It also regulates the LasI-LasR quorum sensing system (Banerjee et al. 2025).
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| Accession Number: | ARU36700.1 |
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| Protein Name: | ARU36700.1 phosphoenolpyruvate-protein phosphotransferase PtsP [Pseudomonas aeruginosa] |
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| Length: | 760 |
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| Molecular Weight: | |
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| Species: | Pseudomonas aeruginosa [287] |
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| Substrate |
protein |
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1: MLNTLRKIVQ EVNSAKDLKA ALGIIVQRVK EAMGTQVCSV YLLDTETQRF VLMATEGLNK
61: RSIGKVSMAP SEGLVGLVGT REEPLNLENA AAHPRYRYFA ETGEERYASF LGAPIIHHRR
121: VMGVLVVQQK ERRQFDEGEE AFLVTMSAQL AGVIAHAEAT GSIRGLGKLG KGIQEAKFVG
181: VPGAPGVGVG KAVVVLPPAD LEVVPDKQVD DIDAEIALFK QALEGVRADM RALSSKLASQ
241: LRKEERALFD VYLMMLDDAS IGNEVKRIIR TGQWAQGALR QVVMEHVQRF ELMDDAYLRE
301: RASDVKDIGR RLLAYLQEER KQNLTYPEQT IIVSEELSPA MLGEVPEGRL VGLVSVLGSG
361: NSHVAILARA MGIPTVMGAV DLPYSKVDGI DLIVDGYHGE VYTNPSAELV RQYSDVVAEE
421: RELSKGLAAL RELPCETLDG HRMPLWVNTG LLADVARAQE RGAEGVGLYR TEVPFMINDR
481: FPSEKEQLAI YREQLSAFHP LPVTMRTLDI GGDKALSYFP IKEDNPFLGW RGIRVTLDHP
541: EIFLVQTRAM LKASEGLDNL RILLPMISGT HELEEALHLI HRAWGEVRDE GVDIAMPPIG
601: MMVEIPAAVY QTRELARQVD FLSVGSNDLT QYLLAVDRNN PRVADLYDYL HPAVLHALKK
661: VVDDAHLEGK PVSICGEMAG DPAAAVLLMA MGFDSLSMNA TNLPKVKWLL RQITLDKARD
721: LLGQLLTFDN PQVIHSSLHL ALRNLGLGRV INPAATVQP