2.A.6.2.33
Multidrug efflux pump, MexVW-OprM (exports fluoroquinolones, macrolides, chloramphenicol, tetracycline, erythromycin, ethidium bromide and acriflavine, and elevated ethidium bromide extrusion was observed (Li et al. 2003). MexAB-OprM and MexVW-OprM were both expressed at increased levels in the presence of elevated Ca2+ (Khanam et al. 2017).
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| Accession Number: | BAA28694.1 |
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| Protein Name: | BAA28694.1 OprM [Pseudomonas aeruginosa] |
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| Length: | 486 |
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| Molecular Weight: | |
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| Species: | Pseudomonas aeruginosa [287] |
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| Substrate |
macrolide, fluoroquinolone antibiotic, chloramphenicol, tetracycline, erythromycin A, 3,6-diamino-10-methylacridinium chloride, ethidium bromide |
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1: MKRSFLSLAV AAVVLSGCSL IPDYQRPEAP VAAAYPQGQA YGQNTGAAAV PAADIGWREF
61: FRDPQLQQLI GVALENNRDL RVAALNVEAF RAQYRIQRAD LFPRIGVDGS GTRQRLPGDL
121: STTGSPAISS QYGVTLGTTA WELDLFGRLR SLRDQALEQY LATEQAQRSA QTTLVASVAT
181: AYLTLKADQA QLQLTKDTLG TYQKSFDLTQ RSYDVGVASA LDLRQAQTAV EGARATLAQY
241: TRLVAQDQNA LVLLLGSGIP ANLPQGLGLD QTLLTEVPAG LPSDLLQRRP DILEAEHQLM
301: AANASIGAAR AAFFPSISLT ANAGTMSRQL SGLFDAGSGS WLFQPSINLP IFTAGSLRAS
361: LDYAKIQKDI NVAQYEKAIQ TAFQEVADGL AARGTFTEQL QAQRDLVKAS DEYYQLADKR
421: YRTGVDNYLT LLDAQRSLFT AQQQLITDRL NQLTSEVNLY KALGGGWNQQ TVTQQQTAKK
481: EDPQA