3.A.1.105.26
Putative ABC transporter with two membrane proteins, both with 6 TMSs, one with them in a 2 + 2 + 2 TMS arrangement, the other in a 2 + 3 + 1 TMS arrangement. The two genes encoding these proteins are next to each other on the chromosome. The ATPase is fused to the first of these two membrane protein domains (acc # C7QI22). These two genes, presumable encoding an ABC exporter, are adjacent to lantibiotic biosynthesis genes. Therefore their function may be to export a lantibiotic. The N-terminal hydrophilic domain of C7QI22 is an S2P-M50-like peptidase (TC# 9.B.149) that may process the pro-lantibiotic during export.
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| Accession Number: | C7QI21 |
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| Protein Name: | Transport permease protein |
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| Length: | 258 |
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| Molecular Weight: | 27072.00 |
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| Species: | Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897) [479433] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSAGNPNASG TPLGALSVAI ARSYYRDKVT LFFTFAFPLI FLVVFGVLFR DQTVGGGGFI
61: ASTAAGVLSW AVATSALFGV AYTLMHWRST EVLRVIRMTP TRLPTVMGSR FLVAVAVALV
121: QAVFFVGVAM LPVFGLRLSG RAVLAIPAIL AGVTAFFALG LLVSVVASSS EAIAAIANCV
181: MTPMAFLSGT FYPISLSPRW IQDVSWVLPL RYLVNGTVGP VGGTGGISTV LVSCAALLGF
241: TALFAGLAAR YFRWSREA