3.A.1.105.26
Putative ABC transporter with two membrane proteins, both with 6 TMSs, one with them in a 2 + 2 + 2 TMS arrangement, the other in a 2 + 3 + 1 TMS arrangement. The two genes encoding these proteins are next to each other on the chromosome. The ATPase is fused to the first of these two membrane protein domains (acc # C7QI22). These two genes, presumable encoding an ABC exporter, are adjacent to lantibiotic biosynthesis genes. Therefore their function may be to export a lantibiotic. The N-terminal hydrophilic domain of C7QI22 is an S2P-M50-like peptidase (TC# 9.B.149) that may process the pro-lantibiotic during export.
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| Accession Number: | C7QI22 |
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| Protein Name: | ABC transporter related |
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| Length: | 741 |
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| Molecular Weight: | 79675.00 |
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| Species: | Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897) [479433] |
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| Number of TMSs: | 6 |
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| Substrate |
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1: MTATWLDQSP ARAAHVAIGP GMLRGAALVY PVKNTSTGAR YELGPREHFV LERLDGIRTL
61: DAIGVDYAAA FDKRLGETAW LQLLSLFGSR GLLSGGEAAE PAAAAKRVKR ESKKGFPAGD
121: IVMFDPEPVI GFLLRVLRPV LTRRVAIPVV LALIAVEAVI LAHVGELARE SWHFAKQPSL
181: IPMVFSLYGV SLLIHELGHG VIGERFGGRA TEVGLRYRLP ALGFYCTVED MPLFRSRWRR
241: VATAAAGVAA DVAFQVPFYV LWAALPAGDA TRTAIAMLLM YKTAGILFNL LPLPPLDGYL
301: MLSHALNISR LAVSSGVYIS QLVHRNPAAR RYPRRAVVAY LCYPLIAAGF VLPAVSGVCW
361: YLLSAFPSPY GWLVIGALVL LNVAPPLVKR LRGKRPAQVT EAPSPVETPE PVATEPLPLP
421: ARLSTSLSTR EKVRMDAITD SATAAIVVQH VRKTYGAVSA CRDVSLSVAE GELFGVLGPN
481: GAGKTTLIEI LEGLRRPDSG TVSVLGAEPW QRDSRVLLRI GVQTQASAFF TRLTALEHLE
541: TVAALYGAPR RAAREAIERF GLTASAGTRV ERLSGGQRQR LGIAAALVHD PDLVFLDEPT
601: AALDPRARLD LWDLMREIRD RGKTIVYTTH QLDEAEALCD RVAIMSGGRV VAVGDPLELV
661: DSLDQPVRVF VPCERISVGA ARGLPGVEEA RTEGASTVIA TRAPGLVLSA VTEIAGVQGI
721: RTRTASLEDV YLALTGKDFA A