3.A.1.135.7
Multidrug exporter, EfrAB. Confers resistance to many structurally unrelated antimicrobial agents, such as
norfloxacin, ciprofloxacin, doxycycline, acriflavine,
4,6-diamidino-2-phenylindole, tetraphenylphosphonium chloride,
daunorubicin, and doxorubicin (Lee et al. 2003). Induced by half minimal inhibitory concentrations (MIC) of gentamicin, streptomycin and chloramphenicol which are also exporter (Lavilla Lerma et al. 2014). In some strains, this system may not be the primary drug exporter (Hürlimann et al. 2016).
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| Accession Number: | J6RCW6 |
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| Protein Name: | ABC transporter, ATP-binding protein |
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| Length: | 567 |
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| Molecular Weight: | 63446.00 |
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| Species: | Enterococcus faecalis ERV85 [1134799] |
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| Number of TMSs: | 7 |
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| Substrate |
norfloxacin, Ciprofloxacin, Doxycycline, acriflavine, 4,6-diamidino-2-phenylindole, TPP chloride, daunorubicin, doxorubicin |
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1: MRYKKLLFAD FICVFGFILI ELGLPTILAR MIDKGIIPKD MDYIYQQGIW MVVITIIGVA
61: MNILLGYFGA RITTNIVRDI RDDLFEKIQT FSHSEYESIG VSSLITRTTN DAYQIMLFMG
121: NILRLGFMTP VMFIASLYMV MRTSPSLGMY VLGALPFLLL AVVGIARLSE PLSKKQQKNL
181: DGINGILREN LSGLRVIRAF VNEKFEESRF NKVNETYTKS SKSLFRLMAA AQPGFFFLFN
241: IVMVLIIWSG TVQISHGDLE VGNLIAFIEY IFHALFSFML FASVFMMYPR AAVSASRIQE
301: ALDMEPAIRE EEGVTETATK GYLEFKNVTF AYPGHAESPV IRNVSFKASP GETVAFIGST
361: GSGKSTLIQL IPRFYDVSEG EILIDGVNVK DYQLSALRNK IGYIPQKALL FTGTIADNLR
421: YGKEDATLEE MERAIDIAQA TEFVSQKPQG YDEPLSEGGT NFSGGQKQRL AIARAIIRNP
481: EIYIFDDSFS ALDYQTDANL RARLKKETTE STVLIVAQRV GTIMHADRIV VLNEGDVVGI
541: GTHRELLETC PIYYDIAASQ LSEEELA