3.A.2.2.11
Potentially 9 component V-type ATPase. This vacuolar H+ ATPase (V-ATPase), was
dispensable for promastigote growth in Leishmania mexicano in vitro but essential for survival
of the disease-causing amastigotes (Albuquerque-Wendt et al. 2025).
1. A subunit of 637 aas and 0 TMSs
2. B subunit of 496 aas and possibly 1 N-terminal TMS
3. C subunit of 381 aas and possibly 2 or 4 TMSs
4. 16 kDa proteolipid subunit of 150 aas with 4 TMSs
5. 191 aa subunit with 5 TMSs
6. 224 aa subunit with 5 TMSs
7. 772 aa A subunit with 7 putative TMSs
8. 741 aa subunit with 6 putative TMSs
9. 472 aa subunit with 6 putative TM
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| Accession Number: | KEG10631.1 |
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| Protein Name: | KEG10631.1 putative V-type ATPase, A subunit [Trypanosoma grayi] |
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| Length: | 638 |
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| Molecular Weight: | |
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| Species: | Trypanosoma grayi [71804] |
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| Substrate |
hydron |
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1: MARDHNPYEA ENRMGSVKAV SGPVVIAENM SGSAMYELVQ VGSFRLVGEI IRLEGDTATI
61: QVYEETDGLT VGDPVYCTGK PLDTATIQVY EETDGLTVGD PVYCTGKPLS LELGPGIMSE
121: IFDGIQRPLD TIYRMVENVF IPKGVQVKAL NDHKMWDFTP RVRVGDLVTG GDILGTVVEN
181: SLMNNHSIMV PPNVQGRITS VEPSGNYTLQ DNIVELEHNG KKRTLKLMHR WPVRTPRPVA
241: VKESGNHPLL TGQRVLDALF PSVQGGTCAI PGAFGCGKTV ISQALSKYSN SDAVIYVGCG
301: ERGNEMAEVL MDFPTLTTVI DGREESIMKR TCLVANTSNM PVAAREASIY TGITLAEYYR
361: DMGKHIAMMA DSTSRWAEAL REISGRLAEM PADGGYPAYL SARLASFYER AGRVTCIGGP
421: KREGSVTIVG AVSPPGGDFS DPVTSATLGI VQVFWGLEKR LAQRKHFPSV NWLISYSKYL
481: KVLEPFFNTF DSDYMRLRSV SAEILQREEE LQEIVQLVGK DSLSESDKII LETAKIIREE
541: FLQQNAFTPY DKFCPLYKTC WMLRNIVTFY EEGQRVVAES AGDQKITWNY IREKIPHIYT
601: GLTEMKFRDP AEGKEVNIDY FKKQNEDIVL AFASLLQ