3.A.2.2.11
Potentially 9 component V-type ATPase. This vacuolar H+ ATPase (V-ATPase), was
dispensable for promastigote growth in Leishmania mexicano in vitro but essential for survival
of the disease-causing amastigotes (Albuquerque-Wendt et al. 2025).
1. A subunit of 637 aas and 0 TMSs
2. B subunit of 496 aas and possibly 1 N-terminal TMS
3. C subunit of 381 aas and possibly 2 or 4 TMSs
4. 16 kDa proteolipid subunit of 150 aas with 4 TMSs
5. 191 aa subunit with 5 TMSs
6. 224 aa subunit with 5 TMSs
7. 772 aa A subunit with 7 putative TMSs
8. 741 aa subunit with 6 putative TMSs
9. 472 aa subunit with 6 putative TM
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| Accession Number: | KEG12320.1 |
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| Protein Name: | KEG12320.1 vacuolar proton translocating ATPase subunit A [Trypanosoma grayi] |
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| Length: | 773 |
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| Molecular Weight: | |
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| Species: | Trypanosoma grayi [71804] |
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| Number of TMSs: | 7 |
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| Substrate |
hydron |
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1: MPREAASGLW RSEDMKMLQL TMQREAAHDS VLKLGQLAGF QFIDLNTDVS AFQRDFVQEV
61: RRCDDMERKL RYLQDEINKA GVTAIPDLVA EKETMFSLEH KVDERESEVR ELNEQYQSLI
121: EERNRSREHL EVLSREFGGS STQSRGLNLL TGVIPKERLA TLERLVYRTT RGNSVMQTDD
181: IKTPFYNTTT NQAVYKCIFG IYFPAPRLRE TLSKISEVNG ATLYAYAENE EQLQGMRDSL
241: QNQVETVTHT LHQSALRQRQ LLMALAGNVY EWRRAVAVEK AVYSTMNMLR FSGATAVAKG
301: WAPVRALDDI RAVLQEAEHL SGAQVLTVVE ELVAKGTPPT YFRTNKITSS FQGIVDSYGM
361: ARYKEVNPGV FTIVTFPYLF GVMYGDIGHG VILTVFAAFL IFMEKSWEGK PLNEIFAMIF
421: GGRYLLLFMG LFAVYLGFLY NDMFGFSVEV FASGYRWPQL PPNGPEGTVR PLSPTGVTPD
481: SSVIFGIDSA WAETENKLEF YNSIKMKCSV IIGVVQMMAG VVLSLMNHLY FGDKLQVWFR
541: FVPEIVFLSC TFGYMCLLIV VKWCIAWENR THDAPSLLET MTNFFLQPGT VTVPLYKGQA
601: VIQVILLLIA FAMVPLLLCV IPYMEKKHHD EKMARKSLLD ESDEEEDDFD FSEVMIHQVI
661: HTIEYVLGCV SNTASYLRLW ALSLAHSQLS EVFWNFAFLL TVGLDGGLGL FVFVGFCVWM
721: CATLGVLLGM ESLSAFLHAL RLHWVEFNNK FYAADGHAFA PFDVAEVLSK LN