3.A.2.2.11
Potentially 9 component V-type ATPase. This vacuolar H+ ATPase (V-ATPase), was
dispensable for promastigote growth in Leishmania mexicano in vitro but essential for survival
of the disease-causing amastigotes (Albuquerque-Wendt et al. 2025).
1. A subunit of 637 aas and 0 TMSs
2. B subunit of 496 aas and possibly 1 N-terminal TMS
3. C subunit of 381 aas and possibly 2 or 4 TMSs
4. 16 kDa proteolipid subunit of 150 aas with 4 TMSs
5. 191 aa subunit with 5 TMSs
6. 224 aa subunit with 5 TMSs
7. 772 aa A subunit with 7 putative TMSs
8. 741 aa subunit with 6 putative TMSs
9. 472 aa subunit with 6 putative TM
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| Accession Number: | KEG13462.1 |
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| Protein Name: | KEG13462.1 vacuolar proton-ATPase-like protein [Trypanosoma grayi] |
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| Length: | 742 |
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| Molecular Weight: | |
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| Species: | Trypanosoma grayi [71804] |
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| Number of TMSs: | 6 |
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| Substrate |
hydron |
|---|
1: MPPEGASGLW RSEDMVRLDI ITQREVLHET VLRLGLIGKA QFVDLNEDMT AFMRPYTPEI
61: RHLDELERKL SVVAKELERV SCLEKEEECA PPFKAQEDIL SLMRLTMLDE VEERVNTVVA
121: ELHAVNESLQ GLRREINYNH ELSLLHTRLQ ELMPSRTVQS FAADVQTPHV LGVIAAEKAE
181: ILYAVVYRAT KGNSLIELDN RPVMLLDPDT GERCVAKTPF AVFAPSPGVL ERVERLLGSL
241: GATVHTMSGV SHQTREELNR SMEELQLMYG RVEQRKMELL TQHNRHHRAN LRFVQIEKQV
301: FAQMNFCAVS GTTCTASVWI PQKYEEALST ALKDAVHASS GSVPSVVSPH LSQCNPPTYF
361: ETNAFTESFQ SIVDSYGMAR YKEVNPGVFT IVTFPYLFGI MYGDIGHGML LMFFALYFIA
421: MERSWRGYRL NEILAMLFGG RYLLLLMSLF SIYMGALYND FFGFSVGMFS SAYSWPPIAE
481: QKGTVEPTEV QNQTRVYLFG LDAAWAETEN KLEFYNSVKM KCAVIVGVLQ MLTGNVLSLL
541: NYLRNREFAK ILFLFIPETV FLLCTFGYMS VAIVIKWCTR WENTSEAPSI LETMTNFFLQ
601: PGTVTQPLFN GQAVLQLVFL LVAFAMVPVM LVMMPLVELR KERRRRAEYA VLRDGASMRS
661: IGAGDGRQHT SSVLVGSRNV SPADGVDFVP SRHSLTAPDD VYSNSGNAGV VADVTPHFDF
721: SEVAIHYVIH TIEYVLGCVX M