TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.27.6
Mce1A-F hetero-hexameric uptake porter for mycolic acid and fatty acids. The structure of Mce1A is known (Asthana et al. 2021); MceE = LprK. Each of the four Mce complexes in Mtb (Mce1-4) comprises six substrate-binding proteins (SBPs; MceA-F), each of which contains four conserved domains (N-terminal transmembrane, MCE, helical and C-terminal unstructured tail domains). In the crystal structure of the MCE domain of Mce4A (MtMce4A39-140) a domain-swapped conformation is observed. The fact that there are six SBPs in each Mtb mce operon suggests that the MceA-F SBPs from Mce1-4 may form heterohexamers. The helical domains interact with the detergent micelle, suggesting that when assembled, the helical domains of MceA-F may form a hydrophobic pore for lipid transport, as observed in PqiB of E. coli (Asthana et al. 2021). 

Accession Number:O07414
Protein Name:Mce-family protein Mce1B
Length:346
Molecular Weight:37727.00
Species:Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [83332]
Number of TMSs:1
Substrate fatty acid, mycolic acid

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MKITGTVVKL GIVSVVLLFF TVMIIVIFGQ MRFDRTNGYT AEFSNVSGLR QGQFVRASGV 
61:	EIGKVKALHL VDGGRRVRVE FNIDRSVPLY QSTTAQIRYS DLIGNRYVEL KRGEGKGAND 
121:	LLPPGGLIPL SRTSPALDLD ALIGGFKPVF RALDPAKVNN IANALITVFQ GQGGTINDIL 
181:	DQTAQLTSQI AERDQAIGEV VKNLNIVLDT TVKHRKEFDE TVNNLENLIT GLRNHSDQLA 
241:	GGLAHISNGA GTVADLLAEN RTLVRKAVSY LDAIQQPVID QRVELDDLLH KTPTALTALG 
301:	RANGTYGDFQ NFYLCDLQIK WNGFQAGGPV RTVKLFSQPT GRCTPQ