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3.A.1.27.6
Mce1A-F hetero-hexameric uptake porter for mycolic acid and fatty acids. The structure of Mce1A is known (Asthana et al. 2021); MceE = LprK. Each of the four Mce complexes in Mtb (Mce1-4) comprises six substrate-binding proteins (SBPs; MceA-F), each of which contains four conserved domains (N-terminal transmembrane, MCE, helical and C-terminal unstructured tail domains). In the crystal structure of the MCE domain of Mce4A (MtMce4A39-140) a domain-swapped conformation is observed. The fact that there are six SBPs in each Mtb mce operon suggests that the MceA-F SBPs from Mce1-4 may form heterohexamers. The helical domains interact with the detergent micelle, suggesting that when assembled, the helical domains of MceA-F may form a hydrophobic pore for lipid transport, as observed in PqiB of E. coli (Asthana et al. 2021). 

Accession Number:O07417
Protein Name:Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E)
Length:390
Molecular Weight:42240.00
Species:Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [83332]
Number of TMSs:1
Substrate fatty acid, mycolic acid

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FASTA formatted sequence
1:	MMSVLARMRV MRHRAWQGLV LLVLALLLSS CGWRGISNVA IPGGPGTGPG SYTIYVQMPD 
61:	TLAINGNSRV MVADVWVGSI RAIKLKNWVA TLTLSLKKDV TLPKNATAKI GQTSLLGSQH 
121:	VELAAPPDPS PVPLKDGDTI PLKRSSAYPT TEQTLASIAT LLRGGGLVNL EGIQQEINAI 
181:	VTGRADQIRA FLGKLDTFTD ELNQQRDDIT RAIDSTNRLL AYVGGRSEVL NRVLTDLPPL 
241:	IKHFADKQEL LINASDAVGR LSQSADQYLS AARGDLHQDL QALQCPLKEL RRAAPYLVGA 
301:	LKLILTQPFD VDTVPQLVRG DYMNLSLTLD LTYSAIDNAF LTGTGFSGAL RALEQSFGRD 
361:	PETMIPDIRY TPNPNDAPGG PLVERGNRQC