The Cag pathogenicity island (PAI) proteins (Kutter et al., 2008). CagD (Cag24) is essential for CagA translocation and maximal induction of interleukin-8 secretion (Cendron et al., 2009). It is required for a pro-inflammatory response and multiple cytoskeletal and gene regulatory effects in gastric epithelial cells. Its molecular properties are described in a review by Fischer (2011). Cag16 (CagM) (of unknown function and not dermonstrably homologous to proteins of type IV secretion systems in other bacteria) has 3-4 TMSs and is essential for CagA export. It may therefore be a core protein of the Cag complex (Ling et al. 2013).
|Species:||Helicobacter pylori (Campylobacter pylori)  |
|Location1 / Topology2 / Orientation3:
Membrane1 / Multi-pass membrane protein2
1: MFEKWIGLTL LLNSLAYPCQ KVTISFKQYE NLLHIHQKGC DNEVMCRTLI SIALLESSLG
61: LNNRREKSLK DTSYSMFHIT LNTAKKFYPT YSKTLLKFKL LNDVGFAIQL AKQILKENFD
121: YYKQKHPNKS VYQLVEMAIG AYNGGMKHNP NGAYVKKFRC IYSQVRYNE