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3.A.1.3.13
Uptake system for L-cystine (Km=2.5 μM), L-cystathionine, L-djenkolate ( 2-amino-3-[(2-amino-3-hydroxy-3-oxopropyl)sulfanylmethylsulfanyl] propanoic acid), and S-methyl-L-cysteine (Burguière et al., 2004, Burguière et al., 2005)

Accession Number:O34315
Protein Name:TcyL (YtmL)
Length:239
Molecular Weight:26239.00
Species:Bacillus subtilis [1423]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate S-methylcysteine, cystathionine, L-djenkolic acid

Cross database links:

RefSeq: NP_390814.1   
Entrez Gene ID: 936115   
Pfam: PF00528   
KEGG: bsu:BSU29360   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006865 P:amino acid transport

References (4)

[1] “Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region.”  Lapidus A.et.al.   9387221
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “Global expression profile of Bacillus subtilis grown in the presence of sulfate or methionine.”  Auger S.et.al.   12193636
[4] “Three different systems participate in L-cystine uptake in Bacillus subtilis.”  Burguiere P.et.al.   15262924

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MEKAFDMNMI GDFVPTLTAY LPVTLYILTL SLLFGFVLGL FLALPRIYNI PIVNQLAKVY 
61:	ISFFRGTPIM VQLFIVFYGI PALTGLIGID TSKMDPFYAA VATYALSNAA AAAEIIRAGV 
121:	GSVDKGQTEA AYSIGLSGSQ AFRRIVLPQA LVQAFPNMGN MVISSLKDTS LAFSIGVMDM 
181:	SGRGQTLITS SNHSLEVYIA LSIVYYAVAV LFEWFFRVAE KRIKKNQTRI VTVFDMNIH