TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.12.4
Uptake system for choline, L-carnitine, D-carnitine, glycine betaine, proline betaine, crotonobetaine, γ-butyrobetaine, dimethylsulfonioacetate, dimethylsulfoniopropionate, ectoine and choline-O-sulfate

Accession Number:O34742
Protein Name:OPCD aka OpuCD
Length:229
Molecular Weight:24551.00
Species:Bacillus subtilis [1423]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate L-proline betaine, choline, glycine betaine, ectoine, carnitinium, (carboxymethyl)(dimethyl)sulfonium, (E)-4-(trimethylammonio)but-2-enoate, 4-(trimethylammonio)butanoate, S,S-dimethyl-beta-propiothetin

Cross database links:

RefSeq: NP_391260.1   
Entrez Gene ID: 937199   
Pfam: PF00528   
KEGG: bsu:BSU33800   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006865 P:amino acid transport

References (2)

[1] “Two evolutionarily closely related ABC transporters mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine in Bacillus subtilis.”  Kappes R.M.et.al.   10216873
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MEVLQQLGTY YSQNGGYVLQ EFYRHFLMSV YGVLFAAIVG IPLGILIARY RRLSGWVFAV 
61:	TNVIQTIPAL AMLAVLMLVM GLGANTVILS LFLYSLLPII RNTYTGIISI EHAYLESGKA 
121:	MGMTKFQVLR MVELPLALSV IMAGLRTALV IAIGITAIGT FVGAGGLGDI IVRGSNATNG 
181:	TAIILAGAIP TALMAVIADL VMGWLERALS PIKKKKGNFI IADRKTTSI