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3.A.1.3.13 Uptake system for L-cystine (Km=2.5 μM), L-cystathionine, L-djenkolate ( 2-amino-3-[(2-amino-3-hydroxy-3-oxopropyl)sulfanylmethylsulfanyl] propanoic acid), and S-methyl-L-cysteine (Burguière et al., 2004, Burguière et al., 2005)
Accession Number:	O34852
Protein Name:	TcyK (YtmK)
Length:	270
Molecular Weight:	30241.00
Species:	Bacillus subtilis [1423]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Lipid-anchor²
Substrate	S-methylcysteine, cystathionine, L-djenkolic acid

Structure:
RefSeq:	NP_390815.1
Entrez Gene ID:	937359
Pfam:	PF00497
KEGG:	bsu:BSU29370
Gene Ontology GO:0030288 C:outer membrane-bounded periplasmic space GO:0005886 C:plasma membrane GO:0005215 F:transporter activity GO:0006865 P:amino acid transport
References (4) [1] “Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region.” Lapidus A.et.al. 9387221 [2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.” Kunst F.et.al. 9384377 [3] “Global expression profile of Bacillus subtilis grown in the presence of sulfate or methionine.” Auger S.et.al. 12193636 [4] “Three different systems participate in L-cystine uptake in Bacillus subtilis.” Burguiere P.et.al. 15262924
2O1M

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MKTKTAFMAI LFSLITVLSA CGAGSQTTGA GQKKVQTITV GTGTQFPNIC FIDEKGDLTG 
61:	YDVELIKELD KRLPHYKFTF KTMEFSNLLV SLGQHKVDIV AHQMEKSKER EKKFLFNKVA 
121:	YNHFPLKITV LQNNDTIRGI EDLKGKRVIT SATSNGALVL KKWNEDNGRP FEIAYEGQGA 
181:	NETANQLKSG RADATISTPF AVDFQNKTST IKEKTVGNVL SNAKVYFMFN KNEQTLSDDI 
241:	DKALQEIIDD GTLKRLSLKW LGDDYSKEQY

3.A.1.3.13
Uptake system for L-cystine (Km=2.5 μM), L-cystathionine, L-djenkolate ( 2-amino-3-[(2-amino-3-hydroxy-3-oxopropyl)sulfanylmethylsulfanyl] propanoic acid), and S-methyl-L-cysteine (Burguière et al., 2004, Burguière et al., 2005)

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

3.A.1.3.13Uptake system for L-cystine (Km=2.5 μM), L-cystathionine, L-djenkolate ( 2-amino-3-[(2-amino-3-hydroxy-3-oxopropyl)sulfanylmethylsulfanyl] propanoic acid), and S-methyl-L-cysteine (Burguière et al., 2004, Burguière et al., 2005)

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

3.A.1.3.13
Uptake system for L-cystine (Km=2.5 μM), L-cystathionine, L-djenkolate ( 2-amino-3-[(2-amino-3-hydroxy-3-oxopropyl)sulfanylmethylsulfanyl] propanoic acid), and S-methyl-L-cysteine (Burguière et al., 2004, Burguière et al., 2005)