3.A.1.209.3
Haf-4/Haf-9 heterodimeric half transporter of 787 aas and 815 aas, respectively. Probably tranports antigenic peptides. Both proteins localize to the membrane of nonacidic, lysosome-associated, membrane
protein homologue (LMP-1)-positive intestinal granules from larval to
adult stages. Mutants of haf-4 and haf-9 exhibited granular defects in late larval and young adult intestinal
cells, associated with decreased brood size, prolonged defecation cycle,
and slow growth (Kawai et al. 2009). Thus they may mediate intestinal granular formation. HAF-4-HAF-9 heterodimer formation is required for their stabilization (Tanji et al. 2013). The HAF-4- and HAF-9-localizing organelles are distinct intestinal organelles associated with the endocytic pathway (Tanji et al. 2016; Tanji et al. 2017).
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| Accession Number: | O44897 |
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| Protein Name: | HAlF transporter (PGP related) |
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| Length: | 815 |
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| Molecular Weight: | 90793.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 9 |
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| Substrate |
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1: MSSSLYTGGQ ALFICLAFIG LDLLVNVFGL AWNGKYFTFD NIAHWFDLAN YSFLKNPVDF
61: LAVALIRDSI LLGGAVSAWA SPSGFSQVAE NVKNVVFAMM LLIVAFAPSK LLAFYEDDNI
121: RLAVGDWILM IWCIFASLLL QGIWTSVLAH VTEVAAGTGD SLLFGDAEHE ERLRQEEAEK
181: AAEQRETFQL LFRLLGYMGR QWKYYGMAFF FLFCYSLSRV FIPYYTGEVV TAVFGDKASY
241: EKLHKTVFIM GMLSLASTVF GGLRGGSFTY AHATIDRQIR NDLFRSVVKQ EIGFFDMNKT
301: GEICSRLSAD CQTMSNTLSL YMNVLTRNLT MLFGSLIFMF TLSWKLSMIT LINIPIIFLV
361: NKIFGVWYDM LSEETQNSVA KANDVAEEVL SSIRTVKSFA CENYESSRFM TFLNVTLKIA
421: TRKVFVVIGL IWSNELLQMG ILTIVLWYGG HLVIENKVES GLLVSFLLYQ FQLGENLREL
481: GEVWNGLMQA VGASRKVFEF IDRPPRVENT GTYAPDGMTG KIEFRHVAFS YPIRPDLPIM
541: EDLTFTVEPG EVVALVGPSG GGKSSCIAML EHFYEPTSGE VLIDGVPVRE YDHKFLHTKV
601: ALVGQEPVLY ARSVTENIGY GLDKYDDDMV QNSAKLANAH TFIMNDTTDG YNTNVGEKGS
661: QMSGGQKQRI AIARALVRQP VVLLLDEATS ALDAESEHTV QEAISKNLKG KTVILIAHRL
721: STVENADKIV VINKGKVEQL GNHKTLMEQE GLYKQLVQRQ MMSGEDGLDD EIEEPEPARE
781: GGSGRSTRAG ARRIRSPSQS VSQSFLGTSF ASSYL