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3.D.4.7.1
Cytochrome oxidase (Cox1-3)

Accession Number:P00396
Protein Name:Cox1 aka MTCO1 aka COI
Length:514
Molecular Weight:57032.00
Species:Bos taurus (Bovine) [9913]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

Pfam: PF00115   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0070469 C:respiratory chain
GO:0004129 F:cytochrome-c oxidase activity
GO:0009055 F:electron carrier activity
GO:0020037 F:heme binding
GO:0009060 P:aerobic respiration
GO:0022900 P:electron transport chain
GO:0006810 P:transport

References (6)

[1] “Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome.”  Anderson S.et.al.   7120390
[2] “Studies on cytochrome-c oxidase, XIV. The amino-acid sequence of subunit I -- proteinchemical methods for the analysis of a large hydrophobic membrane protein.”  Hensel S.et.al.   2165784
[3] “Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase.”  Buse G.et.al.   10338009
[4] “The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A.”  Tsukihara T.et.al.   8638158
[5] “Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution.”  Tomizaki T.et.al.   10089392
[6] “X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution.”  Fei M.J.et.al.   10771420
Structure:
1OCC   1OCO   1OCR   1OCZ   1V54   1V55   2DYR   2DYS   2EIJ   2EIK   [...more]

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFINRWLFST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGTLLGD DQIYNVVVTA 
61:	HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSFL LLLASSMVEA 
121:	GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMSQYQ 
181:	TPLFVWSVMI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH 
241:	PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD 
301:	TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMMW ALGFIFLFTV GGLTGIVLAN 
361:	SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFVHWFPLF SGYTLNDTWA KIHFAIMFVG 
421:	VNMTFFPQHF LGLSGMPRRY SDYPDAYTMW NTISSMGSFI SLTAVMLMVF IIWEAFASKR 
481:	EVLTVDLTTT NLEWLNGCPP PYHTFEEPTY VNLK