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2.A.37.1.1
Glutathione-regulated K+ efflux protein C, KefC; regulated by ancillary protein KefF (YabF)

Accession Number:P03819
Protein Name:KefC aka TRKC aka B0047
Length:620
Molecular Weight:67796.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

DIP: DIP-10072N
RefSeq: AP_000711.1    NP_414589.1   
Entrez Gene ID: 944773   
Pfam: PF00999    PF02254   
BioCyc: EcoCyc:KEFC-MONOMER    ECOL168927:B0047-MONOMER   
KEGG: ecj:JW0046    eco:b0047   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005488 F:binding
GO:0003824 F:catalytic activity
GO:0015503 F:glutathione-regulated potassium exporter ac...
GO:0015299 F:solute:hydrogen antiporter activity
GO:0008152 P:metabolic process
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (7)

[1] “The cloning and DNA sequence of the gene for the glutathione-regulated potassium-efflux system KefC of Escherichia coli.”  Munro A.W.et.al.   2046548
[2] “Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region.”  Yura T.et.al.   1630901
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Nucleotide sequence of the E coli gene coding for dihydrofolate reductase.”  Smith D.R.et.al.   6159575
[6] “The putative Na+/H+ antiporter (NapA) of Enterococcus hirae is homologous to the putative K+/H+ antiporter (KefC) of Escherichia coli.”  Reizer J.et.al.   1325937
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
Structure:
3EYW   3L9W   3L9X     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MDSHTLIQAL IYLGSAALIV PIAVRLGLGS VLGYLIAGCI IGPWGLRLVT DAESILHFAE 
61:	IGVVLMLFII GLELDPQRLW KLRAAVFGCG ALQMVICGGL LGLFCMLLGL RWQVAELIGM 
121:	TLALSSTAIA MQAMNERNLM VTQMGRSAFA VLLFQDIAAI PLVAMIPLLA TSSASTTMGA 
181:	FALSALKVAG ALVLVVLLGR YVTRPALRFV ARSGLREVFS AVALFLVFGF GLLLEEVGLS 
241:	MAMGAFLAGV LLASSEYRHA LESDIEPFKG LLLGLFFIGV GMSIDFGTLL ENPLRIVILL 
301:	LGFLIIKIAM LWLIARPLQV PNKQRRWFAV LLGQGSEFAF VVFGAAQMAN VLEPEWAKSL 
361:	TLAVALSMAA TPILLVILNR LEQSSTEEAR EADEIDEEQP RVIIAGFGRF GQITGRLLLS 
421:	SGVKMVVLDH DPDHIETLRK FGMKVFYGDA TRMDLLESAG AAKAEVLINA IDDPQTNLQL 
481:	TEMVKEHFPH LQIIARARDV DHYIRLRQAG VEKPERETFE GALKTGRLAL ESLGLGPYEA 
541:	RERADVFRRF NIQMVEEMAM VENDTKARAA VYKRTSAMLS EIITEDREHL SLIQRHGWQG 
601:	TEEGKHTGNM ADEPETKPSS