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3.A.1.2.1
Ribose porter.  RbsA has two ATPase domains fused together; RbsB is the substrate receptor; RbsC has 10 TMSs with N- and C-termini in the cytoplasm and forms a dimer (Stewart and Hermodson, 2003).  ABC importers can be divided into two classes. Type I importers follow an alternating access mechanism driven by the presence of the substrate. Type II importers accept substrates in a nucleotide-free state, with hydrolysis driving an inward-facing conformation.  RbsABC2 seems to share functional traits with both type I and type II importers, as well as possessing unique features, and employs a distinct mechanism relative to other ABC transporters (Clifton et al. 2014).

Accession Number:P04983
Protein Name:RbsA aka B3749
Length:501
Molecular Weight:55042.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Peripheral membrane protein2
Substrate beta-D-ribopyranose

Cross database links:

DIP: DIP-10640N
RefSeq: AP_004038.1    NP_418205.1   
Entrez Gene ID: 948264   
Pfam: PF00005   
BioCyc: EcoCyc:RBSA-MONOMER    ECOL168927:B3749-MONOMER   
KEGG: ecj:JW3728    eco:b3749   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0015407 F:monosaccharide-transporting ATPase activity
GO:0005515 F:protein binding
GO:0008643 P:carbohydrate transport

References (6)

[1] “The nucleotide sequences of the rbsD, rbsA, and rbsC genes of Escherichia coli K12.”  Bell A.W.et.al.   3011793
[2] “DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.”  Burland V.D.et.al.   7686882
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “An analysis of the structure of the product of the rbsA gene of Escherichia coli K12.”  Buckel S.D.et.al.   3086314
[6] “The proteins encoded by the rbs operon of Escherichia coli: I. Overproduction, purification, characterization, and functional analysis of RbsA.”  Barroga C.F.et.al.   8762140

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEALLQLKGI DKAFPGVKAL SGAALNVYPG RVMALVGENG AGKSTMMKVL TGIYTRDAGT 
61:	LLWLGKETTF TGPKSSQEAG IGIIHQELNL IPQLTIAENI FLGREFVNRF GKIDWKTMYA 
121:	EADKLLAKLN LRFKSDKLVG DLSIGDQQMV EIAKVLSFES KVIIMDEPTD ALTDTETESL 
181:	FRVIRELKSQ GRGIVYISHR MKEIFEICDD VTVFRDGQFI AEREVASLTE DSLIEMMVGR 
241:	KLEDQYPHLD KAPGDIRLKV DNLCGPGVND VSFTLRKGEI LGVSGLMGAG RTELMKVLYG 
301:	ALPRTSGYVT LDGHEVVTRS PQDGLANGIV YISEDRKRDG LVLGMSVKEN MSLTALRYFS 
361:	RAGGSLKHAD EQQAVSDFIR LFNVKTPSME QAIGLLSGGN QQKVAIARGL MTRPKVLILD 
421:	EPTRGVDVGA KKEIYQLINQ FKADGLSIIL VSSEMPEVLG MSDRIIVMHE GHLSGEFTRE 
481:	QATQEVLMAA AVGKLNRVNQ E