TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.11.1
Polyamine (putrescine/spermidine) uptake porter.  Plays a role in biofilm formation (Zhang et al. 2013).  Spermidine-preferring (Igarashi and Kashiwagi 1996).

Accession Number:P0AFK6
Protein Name:Spermidine/putrescine transport system permease protein PotC aka B1124
Length:264
Molecular Weight:29111.00
Species:Escherichia coli [83333]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate spermidine, putrescine

Cross database links:

DIP: DIP-48152N
RefSeq: AP_001750.1    NP_415642.1   
Entrez Gene ID: 945691   
Pfam: PF00528   
BioCyc: EcoCyc:POTC-MONOMER    ECOL168927:B1124-MONOMER   
KEGG: ecj:JW1110    eco:b1124   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015417 F:polyamine-transporting ATPase activity
GO:0015846 P:polyamine transport

References (5)

[1] “Characteristics of the gene for a spermidine and putrescine transport system that maps at 15 min on the Escherichia coli chromosome.”  Furuchi T.et.al.   1939142
[2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MIGRLLRGGF MTAIYAYLYI PIIILIVNSF NSSRFGINWQ GFTTKWYSLL MNNDSLLQAA 
61:	QHSLTMAVFS ATFATLIGSL TAVALYRYRF RGKPFVSGML FVVMMSPDIV MAISLLVLFM 
121:	LLGIQLGFWS LLFSHITFCL PFVVVTVYSR LKGFDVRMLE AAKDLGASEF TILRKIILPL 
181:	AMPAVAAGWV LSFTLSMDDV VVSSFVTGPS YEILPLKIYS MVKVGVSPEV NALATILLVL 
241:	SLVMVIASQL IARDKTKGNT GDVK