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3.A.1.2.1
Ribose porter.  RbsA has two ATPase domains fused together; RbsB is the substrate receptor; RbsC has 10 TMSs with N- and C-termini in the cytoplasm and forms a dimer (Stewart and Hermodson, 2003).  ABC importers can be divided into two classes. Type I importers follow an alternating access mechanism driven by the presence of the substrate. Type II importers accept substrates in a nucleotide-free state, with hydrolysis driving an inward-facing conformation.  RbsABC2 seems to share functional traits with both type I and type II importers, as well as possessing unique features, and employs a distinct mechanism relative to other ABC transporters (Clifton et al. 2014).

Accession Number:P0AGI1
Protein Name:Ribose transport system permease protein RbsC aka B3750
Length:321
Molecular Weight:33452.00
Species:Escherichia coli [83333]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate beta-D-ribopyranose

Cross database links:

RefSeq: AP_004037.1    NP_418206.1   
Entrez Gene ID: 948262   
Pfam: PF02653   
BioCyc: EcoCyc:RBSC-MONOMER    ECOL168927:B3750-MONOMER   
KEGG: ecj:JW3729    eco:b3750   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0008643 P:carbohydrate transport

References (6)

[1] “The nucleotide sequences of the rbsD, rbsA, and rbsC genes of Escherichia coli K12.”  Bell A.W.et.al.   3011793
[2] “DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.”  Burland V.D.et.al.   7686882
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Topology of RbsC, a membrane component of the ribose transporter, belonging to the AraH superfamily.”  Park Y.et.al.   9922273
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTTQTVSGRR YFTKAWLMEQ KSLIALLVLI AIVSTLSPNF FTINNLFNIL QQTSVNAIMA 
61:	VGMTLVILTS GIDLSVGSLL ALTGAVAASI VGIEVNALVA VAAALALGAA IGAVTGVIVA 
121:	KGRVQAFIAT LVMMLLLRGV TMVYTNGSPV NTGFTENADL FGWFGIGRPL GVPTPVWIMG 
181:	IVFLAAWYML HHTRLGRYIY ALGGNEAATR LSGINVNKIK IIVYSLCGLL ASLAGIIEVA 
241:	RLSSAQPTAG TGYELDAIAA VVLGGTSLAG GKGRIVGTLI GALILGFLNN GLNLLGVSSY 
301:	YQMIVKAVVI LLAVLVDNKK Q