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3.A.6.1.1
Type III protein secretion complex. Assembly of the YscR,S,T,U,V complex occurs independently of other structural components and involves the formation of a YscV oligomer (Diepold et al., 2011). A C-terminal region of Yersinia pestis YscD binds the outer membrane secretin YscC (Ross and Plano, 2011). YopBD-mediated translocation of T3SS cargo, but not YopBD pore formation, leads to activation of host pathways influencing inflammation, cell death, and response to stress (Kwuan et al. 2013).

Accession Number:P0C2V3
Protein Name:LcrD
Length:704
Molecular Weight:77838.00
Species:Yersinia enterocolitica [630]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate protein polypeptide chain

Cross database links:

RefSeq: NP_052395.1    NP_783668.1   
Entrez Gene ID: 1239126    1239187   
Pfam: PF00771   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0009405 P:pathogenesis
GO:0009306 P:protein secretion

References (2)

[1] “DNA sequence and analysis of the pYVa127/90 virulence plasmid of Yersinia enterocolitica strain A127/90.”  Foultier B.et.al.   14527656
[2] “The lcrE gene is part of an operon in the lcr region of Yersinia enterocolitica O:3.”  Viitanen A.-M.et.al.   2160939

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MNPHDLEWLN RIGERKDIML AVLLLAVVFM MVLPLPPLVL DILIAVNMTI SVVLLMIAIY 
61:	INSPLQFSAF PAVLLVTTLF RLALSVSTTR MILLQADAGQ IVYTFGNFVV GGNFIVGIVI 
121:	FLIITIVQFL VITKGSERVA EVSARFSLDA MPGKQMSIDG DMRAGVIDVN EARERRATIE 
181:	KESQMFGSMD GAMKFVKGDA IAGLIIIFVN ILGGVTIGVT QKGLAAAEAL QLYSILTVGD 
241:	GMVSQVPALL IAITAGIIVT RVSSEDSSDL GSDIGKQVVA QPKAMLIGGV LLLLFGLIPG 
301:	FPTVTFLILA LLVGCGGYML SRKQSRNDEA NQDLQSLLTS GSGAPAARTK AKTSGANKGR 
361:	LGEQEAFAMT VPLLIDVDSS QQEALEAIAL NDELVRVRRA LYLDLGVPFP GIHLRFNEGM 
421:	GEGEYLISLQ EVPVARGELK AGYLLVRESV SQLELLGIPY EKGEHLLPDQ ETFWVSVEYE 
481:	ERLEKSQLEF FSHSQVLTWH LSHVLREYAE DFIGIQETRY LLEQMEGGYG ELIKEVQRIV 
541:	PLQRMTEILQ RLVGEDISIR NMRSILEAMV EWGQKEKDVV QLTEYIRSSL KRYICYKYAN 
601:	GNNILPAYLF DQEVEEKIRS GVRQTSAGSY LALDPAVTES LLEQVRKTIG DLSQIQSKPV 
661:	LIVSMDIRRY VRKLIESEYY GLPVLSYQEL TQQINIQPLG RVCL