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3.D.4.4.1
Cytochrome oxidase including heme A synthase (HAS) and 4 subunits of the cytochrome oxidase.  The 3-d structure of heme A synthase (of 306 aas and 8 TMSs) at 2.2 Å resolution has been solved revealing that the N- and C-terminal halves of HAS consist of four-helix bundles and they align in a pseudo twofold symmetry manner. Each bundle contains a pair of histidine residues and forms a heme-binding domain. The C-half domain binds a cofactor-heme molecule, while the N-half domain is vacant (Niwa et al. 2018). The Sco1 protein, YpmQ, is an accessory protein involved in the assembly of cytochrome c oxidase (Andrews et al. 2004).

Accession Number:P24010
Protein Name:Cytochrome c oxidase subunit 1
Length:622
Molecular Weight:69028.00
Species:Bacillus subtilis [1423]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

Entrez Gene ID: 936898   
Pfam: PF00115   
KEGG: bsu:BSU14900   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0070469 C:respiratory chain
GO:0005507 F:copper ion binding
GO:0004129 F:cytochrome-c oxidase activity
GO:0009055 F:electron carrier activity
GO:0020037 F:heme binding
GO:0009060 P:aerobic respiration
GO:0022900 P:electron transport chain

References (3)

[1] “The Bacillus subtilis cytochrome-c oxidase. Variations on a conserved protein theme.”  Saraste M.et.al.   1847686
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.”  Barbe V.et.al.   19383706

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLNALTEKRT RGSMLWDYLT TVDHKKIAIL YLVAGGFFFL VGGIEAMFIR IQLAKPENAF 
61:	LSAQAYNEVM TMHGTTMIFL AAMPLLFALM NAVVPLQIGA RDVSFPFLNA LGFWLFFFGG 
121:	IFLNLSWFLG GAPDAGWTSY ASLSLHSKGH GIDFFVLGLQ ISGLGTLIAG INFLATIINM 
181:	RAPGMTYMRL PLFTWTTFVA SALILFAFPP LTVGLALMML DRLFGTNFFN PELGGNTVIW 
241:	EHLFWIFGHP EVYILILPAF GIFSEVIPVF ARKRLFGYSS MVFAIVLIGF LGFMVWVHHM 
301:	FTTGLGPIAN AIFAVATMAI AIPTGIKIFN WLLTIWGGNV KYTTAMLYAV SFIPSFVLGG 
361:	VTGVMLAAAA ADYQFHDTYF VVAHFHYVII GGVVFGLLAG VHFWWPKMFG KILHETMGKI 
421:	SFVLFFIGFH LTFFIQHFVG LMGMPRRVYT FLPGQGLETG NLISTIGAFF MAAAVILLLV 
481:	NVIWTSVKGE YVGADPWHDG RTLEWTVSSP PPEYNFKQLP FVRGLDPLWI EKQAGHKSMT 
541:	PAEPVDDIHM PNGSILPLII SFGLFVAAFG LLYRSDYAWG LPVIFIGLGI TFITMLLRSV 
601:	IDDHGYHIHK EELPNDDKGV KA